Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2012 Dec;98(3):501-7. doi: 10.1016/j.diabres.2012.09.022. Epub 2012 Oct 12.
Low-grade inflammation and lipotoxicity contribute to insulin resistance and islet secretory dysfunction that lead to insulin deficiency. We analyzed the associations of several adipocytokines measured at baseline with glycemic progression in non-diabetic Korean subjects after a 4-year follow-up.
In 479 non-diabetic Korean subjects who underwent medical screening in 2003, serum tumor necrosis factor (TNF)-α, interleukin (IL)-6, retinol-binding protein (RBP)-4, monocyte chemoattractant protein (MCP)-1, visfatin and fatty acid-binding protein (FABP)-4 were measured at baseline. After 4 years, changes in glycemia were assessed.
Among the subjects, 79.2% maintained their baseline glycemic status, 14.6% progressed to worse glycemic status (impaired fasting glucose (IFG) to diabetes, normoglycemia to IFG or normoglycemia to diabetes) and 5.8% regressed to normoglycemia after 4 years. Baseline TNF-α and FABP4 showed the highest values in the progression group. In the logistic regression analyses with glycemic progression as the dependent variable and TNF-α and FABP4 as independent variables in separate models, TNF-α and FABP4 individually predicted glycemic progression after adjustment for confounding variables. When both adipocytokines were included in the same model, only FABP4 significantly predicted glycemic progression after 4 years.
TNF-α and FABP4 were significant predictors for glycemic progression in 4 years, with FABP4 being the stronger predictor.
低度炎症和脂毒性导致胰岛素抵抗和胰岛分泌功能障碍，从而导致胰岛素缺乏。我们分析了基线时测量的几种脂肪细胞因子与非糖尿病韩国人在 4 年后血糖进展的关系。
在 2003 年接受医学筛查的 479 名非糖尿病韩国人中，基线时测量了血清肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-6、视黄醇结合蛋白 (RBP)-4、单核细胞趋化蛋白 (MCP)-1、内脏脂肪素和脂肪酸结合蛋白 (FABP)-4。4 年后，评估血糖变化。
在这些受试者中，79.2%保持了基线血糖状态，14.6%血糖状况恶化（空腹血糖受损 (IFG) 进展为糖尿病、正常血糖进展为 IFG 或正常血糖进展为糖尿病），5.8%在 4 年后血糖恢复正常。进展组的基线 TNF-α 和 FABP4 值最高。在以血糖进展为因变量、TNF-α 和 FABP4 为独立变量的逻辑回归分析中，在分别建立模型时，TNF-α 和 FABP4 单独预测了校正混杂因素后的血糖进展。当将两种脂肪细胞因子包含在同一个模型中时，只有 FABP4 显著预测了 4 年后的血糖进展。
TNF-α 和 FABP4 是 4 年内血糖进展的重要预测因子，其中 FABP4 是更强的预测因子。
