Johnston R G, Noseworthy T W, Friesen E G, Yule H A, Shustack A
Department of Adult Intensive Care, Royal Alexandra Hospital, Edmonton, Canada.
Chest. 1990 Mar;97(3):698-701. doi: 10.1378/chest.97.3.698.
Two adults and two children with life-threatening asthma refractory to maximal standard therapy were treated with the inhalational anesthetic agent isoflurane. In each case, the temporal response to the initiation of therapy was striking. All patients survived and none experienced adverse reactions attributable to the drug. Rapid therapeutic benefit, minimal side effects, absence of cumulative toxicity, and ease of administration are factors supporting the use of isoflurane for patients with severe asthma.
两名成年患者和两名儿童患有对最大标准治疗无效的危及生命的哮喘，接受了吸入麻醉剂异氟烷治疗。在每种情况下，治疗开始后的即时反应都很显著。所有患者均存活，且无一例出现药物所致不良反应。快速的治疗效果、最小的副作用、无累积毒性以及给药方便，这些因素都支持将异氟烷用于重度哮喘患者。
