Department of Dermatology, University Hospital of Nice, France.
J Invest Dermatol. 2012 Nov;132(11):2502-4. doi: 10.1038/jid.2012.328.
Vitiligo is characterized by a substantial loss of functional melanocytes in the epidermis and sometimes in hair follicles. Genetic and pathophysiological studies have provided strong evidence that vitiligo is a polygenetic, multifactorial disorder. The key roles of oxidative stress within melanocytes and anti-melanocyte immune responses have been addressed in many studies, but the relationship between these mechanisms remains unclear. In this issue, Toosi et al. report the upregulation of IL-6 and IL-8 after the activation of the unfolded protein response (UPR) following exposure of melanocytes to phenols. Their results shed light on the missing link between oxidative stress and immune responses in vitiligo.
白癜风的特征是表皮和有时毛囊中的功能性黑色素细胞大量丧失。遗传和病理生理学研究为白癜风是一种多基因、多因素疾病提供了有力证据。许多研究已经探讨了黑色素细胞内氧化应激和抗黑色素细胞免疫反应的关键作用，但这些机制之间的关系仍不清楚。在本期中，Toosi 等人报告了在黑色素细胞暴露于酚类物质后，未折叠蛋白反应 (UPR) 激活后白细胞介素 6 (IL-6) 和白细胞介素 8 (IL-8) 的上调。他们的研究结果揭示了白癜风中氧化应激和免疫反应之间缺失的环节。
