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阿普唑仑口服可急性增加伏隔核灌流。

Oral alprazolam acutely increases nucleus accumbens perfusion.

出版信息

Mol Psychiatry. 2013 Sep;18(9):960-1. doi: 10.1038/mp.2012.139. Epub 2012 Oct 16.

DOI:10.1038/mp.2012.139
PMID:23070072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3957329/
Abstract

Benzodiazepines treat anxiety, but can also produce euphoric effects, contributing to abuse. Using perfusion magnetic resonance imaging, we provide the first direct evidence in humans that alprazolam ( acutely increases perfusion in the nucleus accumbens, a key reward-processing region linked to addiction.

摘要

苯二氮䓬类药物可治疗焦虑症，但也可能产生欣快感，从而导致滥用。本研究采用灌注磁共振成像，首次在人类中直接提供了证据，表明阿普唑仑（alprazolam）（急性增加伏隔核的灌注，伏隔核是与成瘾相关的关键奖励处理区域。

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Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI.应用脉冲动脉自旋标记灌注 MRI 测量精神分裂症的静息定量脑血流
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