Department of Psychiatry and Psychotherapy, Division of Old Age Psychiatry and Cognitive Neuropsychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Arch Clin Neuropsychol. 2013 Feb;28(1):72-80. doi: 10.1093/arclin/acs093. Epub 2012 Oct 15.
Alzheimer's disease (AD) patients show better everyday functioning in a familiar setting, but they have a reduced ability to access contextual details and episodes associated with a familiar person or environment. This suggests a dysfunction in the neural networks associated with stimulus identification. Using functional magnetic resonance imaging, we investigated the neural activity during the recognition of personally familiar and unfamiliar faces and places among AD patients and elderly controls. We did not find a group difference in the neural activity within brain areas important for perceptual familiarity recognition. Patients showed reduced activation for familiar stimuli in prefrontal brain areas known to be important for retrieving contextual information for a stimulus when compared with controls. These changes may contribute to how AD patients experience a personally familiar face or place.
阿尔茨海默病（AD）患者在熟悉的环境中表现出更好的日常功能，但他们获取与熟悉的人或环境相关的情境细节和情节的能力下降。这表明与刺激识别相关的神经网络功能障碍。我们使用功能磁共振成像技术，研究了 AD 患者和老年对照组在识别个人熟悉和不熟悉的面孔和地点时的神经活动。我们没有发现大脑中与感知熟悉识别有关的重要区域的神经活动存在组间差异。与对照组相比，患者在与检索刺激的上下文信息有关的前额叶脑区对熟悉刺激的激活减少。这些变化可能有助于解释 AD 患者如何体验熟悉的面孔或地点。
