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PKM2 functions as a histone kinase.

作者信息

Lu Zhimin

出版信息

Cell Cycle. 2012 Nov 15;11(22):4101-2. doi: 10.4161/cc.22325. Epub 2012 Oct 15.

Abstract
摘要

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本文引用的文献

1
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
Cell. 2012 Aug 17;150(4):685-96. doi: 10.1016/j.cell.2012.07.018.
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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.
Mol Cell. 2012 Mar 9;45(5):598-609. doi: 10.1016/j.molcel.2012.01.001. Epub 2012 Feb 2.
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Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.
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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Nature. 2011 Dec 1;480(7375):118-22. doi: 10.1038/nature10598.
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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3.
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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.
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Understanding the Warburg effect: the metabolic requirements of cell proliferation.
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