PKM2 functions as a histone kinase.
作者信息
Lu Zhimin
出版信息
Cell Cycle. 2012 Nov 15;11(22):4101-2. doi: 10.4161/cc.22325. Epub 2012 Oct 15.
Abstract
摘要
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PKM2 functions as a histone kinase.丙酮酸激酶M2作为一种组蛋白激酶发挥作用。
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PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.Cdc25A 对 PKM2 的去磷酸化作用促进了瓦博格效应和肿瘤发生。
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Fructokinase A acts as a protein kinase to promote nucleotide synthesis.果糖激酶A作为一种蛋白激酶促进核苷酸合成。
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本文引用的文献
1
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.PKM2 磷酸化组蛋白 H3，促进基因转录和肿瘤发生。
Cell. 2012 Aug 17;150(4):685-96. doi: 10.1016/j.cell.2012.07.018.
2
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.丙酮酸激酶 M2 通过充当蛋白激酶来调节基因转录。
Mol Cell. 2012 Mar 9;45(5):598-609. doi: 10.1016/j.molcel.2012.01.001. Epub 2012 Feb 2.
3
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.丙酮酸激酶同工酶M2在控制细胞周期进程和肿瘤发生中的非代谢功能
Chin J Cancer. 2012 Jan;31(1):5-7. doi: 10.5732/cjc.011.10446. Epub 2011 Dec 23.
4
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.核 PKM2 在 EGFR 激活时调节β-连环蛋白的转录激活。
Nature. 2011 Dec 1;480(7375):118-22. doi: 10.1038/nature10598.
5
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.活性氧抑制丙酮酸激酶 M2 有助于细胞抗氧化反应。
Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3.
6
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.丙酮酸激酶 M2 是一种受 PHF3 刺激的缺氧诱导因子 1 共激活剂。
Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.
7
Understanding the Warburg effect: the metabolic requirements of cell proliferation.理解瓦伯格效应：细胞增殖的代谢需求。
Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809.
8
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.丙酮酸激酶的M2剪接异构体对癌症代谢和肿瘤生长很重要。
Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.
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