Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Nat Rev Rheumatol. 2012 Nov;8(11):684-9. doi: 10.1038/nrrheum.2012.167. Epub 2012 Oct 16.
Investigations into interactions between the skeletal and immune systems were developed during research into arthritis, with characterization of T-cell-mediated regulation of osteoclastogenesis. A new interdisciplinary field--osteoimmunology--was created, and has since expanded to encompass disciplines including signal transduction, stem cell niches and fundamental immunology. We have witnessed rapid progress in understanding the mechanisms of bone damage in arthritis and the roles of immune molecules in bone, but comparatively less evidence has been provided for the role of bone-derived factors in the immune system. Nevertheless, regulation of immune cells, including haematopoietic stem cells, by bone cells is now a hot topic in this field. Here, I discuss recent advances in osteoimmunology and emerging avenues of basic and clinical investigation.
在关节炎研究过程中，人们对骨骼系统和免疫系统之间的相互作用进行了研究，其中包括 T 细胞介导的破骨细胞生成调控作用。一个新的跨学科领域——骨免疫学诞生了，此后不断扩展，涵盖了信号转导、干细胞龛位和基础免疫学等多个学科。我们见证了在理解关节炎中骨损伤机制和免疫分子在骨骼中的作用方面取得的快速进展，但关于骨骼来源的因子在免疫系统中的作用，证据相对较少。尽管如此，骨骼细胞对免疫细胞（包括造血干细胞）的调控作用，目前仍是该领域的热门话题。在此，我将讨论骨免疫学的最新进展以及基础和临床研究的新兴方向。
