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揭示研究热点：肌肉骨骼疾病中巨噬细胞的文献计量学研究

Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases.

作者信息

Yue Yaohang, Cao Siyang, Cao Fuyang, Wei Yihao, Li Aikang, Wang Deli, Liu Peng, Zeng Hui, Lin Jianjing

机构信息

Department of Bone & Joint Surgery, National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, China.

Shandong Second Medical University, Clinical Medical College, Weifang, China.

出版信息

Front Immunol. 2025 Apr 28;16:1519321. doi: 10.3389/fimmu.2025.1519321. eCollection 2025.

DOI:10.3389/fimmu.2025.1519321
PMID:40356917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12066445/
Abstract

Research on the role of macrophages in musculoskeletal (MSK) diseases has significantly increased in recent years. However, a thorough evaluation of the developmental trajectory of this field, including the contributions of prominent authors and primary research themes, remains insufficient. Furthermore, the identification of emerging research hotspots requires more detailed exploration. This study collated articles and reviews addressing "macrophages in MSK diseases" published between 2004 and 2023, with all data extracted from the Web of Science database. The collected data were analyzed using a variety of bibliometric and visualization tools, such as VOSviewer, CiteSpace, GraphPad Prism, and R packages. Results indicate that China and the United States are the leading contributors in this research domain. Among the many academic institutions involved, Shanghai Jiao Tong University and the University of California stand out as the most productive. The journal "Frontiers in Immunology" had the highest publication output on this topic. The five most frequently explored research domains include Immunology, Rheumatology, Pharmacology and Pharmacy, Cell Biology, and Biochemistry and Molecular Biology. These results offer a comprehensive overview of the current state of research in this field and provide meaningful insights for guiding future studies.

摘要

近年来，关于巨噬细胞在肌肉骨骼（MSK）疾病中作用的研究显著增加。然而，对该领域发展轨迹的全面评估，包括杰出作者的贡献和主要研究主题，仍显不足。此外，确定新兴研究热点需要更详细的探索。本研究整理了2004年至2023年间发表的关于“MSK疾病中的巨噬细胞”的文章和综述，所有数据均从科学网数据库中提取。使用多种文献计量和可视化工具，如VOSviewer、CiteSpace、GraphPad Prism和R软件包，对收集到的数据进行了分析。结果表明，中国和美国是该研究领域的主要贡献者。在众多参与的学术机构中，上海交通大学和加利福尼亚大学最为突出。《免疫学前沿》杂志在该主题上的发表量最高。五个最常探索的研究领域包括免疫学、风湿病学、药理学与制药学、细胞生物学以及生物化学与分子生物学。这些结果全面概述了该领域的当前研究状况，并为指导未来研究提供了有意义的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/2eaf4d32155f/fimmu-16-1519321-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/903c01758d50/fimmu-16-1519321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/63d38fd9661b/fimmu-16-1519321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/5363113ea3c8/fimmu-16-1519321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/50f106e9edb8/fimmu-16-1519321-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/a8fb81aaf415/fimmu-16-1519321-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/61d0990ec358/fimmu-16-1519321-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/bbbbb5aa4206/fimmu-16-1519321-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/8ba5910db98d/fimmu-16-1519321-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/a9a3d6778ee9/fimmu-16-1519321-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/2eaf4d32155f/fimmu-16-1519321-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/903c01758d50/fimmu-16-1519321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/63d38fd9661b/fimmu-16-1519321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/5363113ea3c8/fimmu-16-1519321-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/50f106e9edb8/fimmu-16-1519321-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/a8fb81aaf415/fimmu-16-1519321-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/61d0990ec358/fimmu-16-1519321-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/bbbbb5aa4206/fimmu-16-1519321-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/8ba5910db98d/fimmu-16-1519321-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/a9a3d6778ee9/fimmu-16-1519321-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7691/12066445/2eaf4d32155f/fimmu-16-1519321-g010.jpg

相似文献

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Unveiling research hotspots: a bibliometric study on macrophages in musculoskeletal diseases.

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本文引用的文献

[1]
Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies.

Pharmacol Res. 2025-2

[2]
The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration.

Bone Joint Res. 2024-9-6

[3]
A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain.

J Nanobiotechnology. 2024-8-14

[4]
Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages.

Pharmaceutics. 2024-3-22

[5]
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis.

Ageing Res Rev. 2024-3

[6]
Advancements in Macrophage-Targeted Drug Delivery for Effective Disease Management.

Int J Nanomedicine. 2023

[7]
Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment.

Sci Adv. 2023-8-2

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Smart Strategies to Overcome Drug Delivery Challenges in the Musculoskeletal System.

Pharmaceuticals (Basel). 2023-7-6

[9]
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

Int J Mol Sci. 2022-12-26

[10]
Bibliometric analysis of publications on enthesitis in spondyloarthritis in 2012-2021 based on web of science core collection databases.

Rheumatol Int. 2023-1

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