School of Sport Science, Exercise and Health, University of Western Australia, Crawley, WA, Australia.
Int J Sport Nutr Exerc Metab. 2013 Apr;23(2):178-86. doi: 10.1123/ijsnem.23.2.178. Epub 2012 Oct 11.
The effect of exercise modality and intensity on Interleukin-6 (IL-6), iron status, and hepcidin levels was investigated. Ten trained male triathletes performed 4 exercise trials including low-intensity continuous running (L-R), low-intensity continuous cycling (L-C), high-intensity interval running (H-R), and high-intensity interval cycling (H-C). Both L-R and L-C consisted of 40 min continuous exercise performed at 65% of peak running velocity (vVO2peak) and cycling power output (pVO2peak), while H-R and H-C consisted of 8 × 3-min intervals performed at 85% vVO2peak and pVO2peak. Venous blood samples were drawn pre-, post-, and 3 hr postexercise. Significant increases in postexercise IL-6 were seen within each trial (p < .05) and were significantly greater in H-R than L-R (p < .05). Hepcidin levels were significantly elevated at 3 hr postexercise within each trial (p < .05). Serum iron levels were significantly elevated (p < .05) immediately postexercise in all trials except L-C. These results suggest that, regardless of exercise mode or intensity, postexercise increases in IL-6 may be expected, likely influencing a subsequent elevation in hepcidin. Regardless, the lack of change in postexercise serum iron levels in L-C may indicate that reduced hemolysis occurs during weight-supported, low-intensity activity.
研究了运动方式和强度对白细胞介素 6（IL-6）、铁状态和铁调素水平的影响。10 名训练有素的男性三项全能运动员进行了 4 项运动试验，包括低强度持续跑步（L-R）、低强度持续骑行（L-C）、高强度间歇跑步（H-R）和高强度间歇骑行（H-C）。L-R 和 L-C 均由 40 分钟的连续运动组成，运动强度为峰值跑步速度（vVO2peak）的 65%和骑行功率输出（pVO2peak），而 H-R 和 H-C 则由 8 个 3 分钟的间隔组成，运动强度为 85% vVO2peak 和 pVO2peak。在运动前、运动中和运动后 3 小时抽取静脉血样。每个试验中运动后 IL-6 均显著增加（p<.05），且 H-R 显著高于 L-R（p<.05）。每个试验中运动后 3 小时铁调素水平均显著升高（p<.05）。除 L-C 外，所有试验中运动后即刻血清铁水平均显著升高（p<.05）。这些结果表明，无论运动方式或强度如何，运动后 IL-6 的增加都可以预期，可能会影响随后铁调素的升高。尽管如此，L-C 中运动后血清铁水平没有变化可能表明在负重、低强度活动中发生了减少的溶血。
