Warsaw School of Social Sciences and Humanities, Department of Sport Psychology, Poland.
Cell Immunol. 2013 May-Jun;283(1-2):12-7. doi: 10.1016/j.cellimm.2013.06.006. Epub 2013 Jun 20.
This investigation assessed effects of high-intensity interval exercise (HIE; triple Wingate anaerobic test) on inflammatory markers, iron metabolism and hepcidin concentrations. Group of highly trained judo athletes (TR) and non-trained control males (CG) completed a triple Wingate test separated by 4.5min rest. Venous blood samples were collected before, immediately after, 1h, 24h, and 5days following exercise and analysed for serum of IL-6, IL-10, iron, and ferritin. Physiological response to exercise was also determined. Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p<0.05). Hepcidin returned post testing 24h in TR, whereas in CG it remained elevated during 5days following exercise. Changes in hepcidin did not correlate with shifts in serum IL-6, iron and ferritin concentrations. Gathered data suggest that following HIE, hepcidin increased independently of IL-6 and neither blood nor storage iron affected this phenomena.
本研究评估了高强度间歇训练（HIE；三重蛙跳无氧测试）对炎症标志物、铁代谢和铁调素浓度的影响。一组经过高度训练的柔道运动员（TR）和未经训练的对照组男性（CG）在 4.5 分钟的休息后完成了三重蛙跳测试。在运动前、运动后即刻、1 小时、24 小时和 5 天后采集静脉血样，并分析血清中的白细胞介素 6（IL-6）、白细胞介素 10（IL-10）、铁和铁蛋白。还确定了运动的生理反应。两组运动后 1 小时，IL-6 和铁调素浓度均升高（p<0.05）。TR 组铁调素在测试后 24 小时恢复正常，而 CG 组在运动后 5 天内仍保持升高。铁调素的变化与血清 IL-6、铁和铁蛋白浓度的变化无关。研究结果表明，在高强度间歇训练后，铁调素的增加独立于白细胞介素 6，血液和储存铁均不会影响这一现象。
