The association of serum proteins with preeclampsia.

In 239 pregnant women, 107 with preeclampsia and 132 controls, phenotype frequency distribution of serum group-specific component (Gc) and haptoglobin (Hp) was studied by disc-electrophoresis in polyacrylamide gel. The results demonstrate a significant statistical difference in phenotype frequency distribution of the Gc-system. Gc 2-1 phenotype was expressed significantly in women with preeclampsia compared to controls. Gc 2-1 phenotype may be useful as a genetic marker for early detection of preeclampsia.