Lange V
Humangenetik im Fachbereich Biologie der Universität Frankfurt a. M.
Psychiatr Neurol Med Psychol (Leipz). 1989 Apr;41(4):200-9.
The systematic schizophrenias are marked genetically by a significant surplus of the Gc serum type 1-1 (p less than 0.0005), what can be demonstrated by the separated analysis of the hebephrenias (p less than 0.0005), paraphrenias (p less than 0.01) and catatonias (p less than 0.05) also. Furtheron there is some evidence that the Gc subtype 1F plays a predominant role within the Gc 1-1 excess (p less than 0.01). The unsystematic schizophrenias (periodic catatonias and affective paraphrenias) do not deviate in their Gc distribution from the corresponding control values, but they exhibit contrary to the systematic forms a surplus of the haptoglobin serum group 2-2 like phasic psychoses. The marker findings are discussed with respect to the relevant data of biological psychiatry and biochemical genetics.
系统性精神分裂症在基因上的特征是Gc血清1-1型显著过剩（p小于0.0005），这一点在青春期痴呆型精神分裂症（p小于0.0005）、偏执型精神分裂症（p小于0.01）和紧张型精神分裂症（p小于0.05）的单独分析中也得到了证实。此外，有证据表明Gc亚型1F在Gc 1-1过剩中起主要作用（p小于0.01）。非系统性精神分裂症（周期性紧张症和情感性偏执狂）的Gc分布与相应的对照值没有偏差，但与系统性类型相反，它们表现出血清触珠蛋白2-2组过剩，类似于发作性精神病。根据生物精神病学和生化遗传学的相关数据对这些标志物发现进行了讨论。
