• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Bladder carcinoma with shadow cell differentiation: a case report with immunohistochemical analyses.伴有影细胞分化的膀胱癌：一例免疫组化分析报告
Int J Clin Exp Pathol. 2012;5(8):840-4. Epub 2012 Oct 1.
2
Immunohistochemical Localization of Phosphorylated and Unphosphorylated Form of β-catenin With Regard to Shadow Cell and Squamous Differentiation in Cutaneous Pilomatricoma.免疫组织化学定位磷酸化和非磷酸化 β-连环蛋白在皮肤毛发基质瘤中的影细胞和鳞状分化。
Am J Dermatopathol. 2020 Nov;42(11):835-841. doi: 10.1097/DAD.0000000000001655.
3
Urothelial Carcinoma with shadow cell, lipid cell and sebaceous (skin adnexal) differentiation: Clinicopathological and immunohistochemical study of 10 cases.伴有影细胞、脂质细胞及皮脂腺（皮肤附属器）分化的尿路上皮癌：10例临床病理及免疫组化研究
Ann Diagn Pathol. 2015 Oct;19(5):314-9. doi: 10.1016/j.anndiagpath.2015.07.002. Epub 2015 Jul 8.
4
Shadow cell differentiation from squamoid morule in endometrial adenoacanthoma.子宫内膜腺棘皮瘤中鳞状小体向影细胞的分化。
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13120-4. eCollection 2015.
5
[Urothelial hyperplastic lesion with endophytic growth pattern: a clinicopathologic study].[具有内生性生长模式的尿路上皮增生性病变：一项临床病理研究]
Zhonghua Bing Li Xue Za Zhi. 2011 May;40(5):319-23.
6
Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation.小窝蛋白-1和小窝蛋白-2在膀胱尿路上皮癌中的表达与肿瘤分级及鳞状分化相关。
Am J Clin Pathol. 2003 Jul;120(1):93-100. doi: 10.1309/292N-HAYN-WAVR-EJ37.
7
Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases.p63、p53和MIB-1在膀胱癌中的免疫组织化学表达。158例组织芯片研究
Virchows Arch. 2006 Mar;448(3):319-24. doi: 10.1007/s00428-005-0092-2. Epub 2005 Nov 8.
8
Shadow cell differentiation in endometrioid carcinomas of the uterus. Its frequent occurrence and beta-catenin expression.子宫子宫内膜样癌中的影细胞分化。其常见性及β-连环蛋白表达。
Cesk Patol. 2015;51(3):123-6.
9
Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma.模仿尿路上皮癌的Florid von Brunn巢：与尿路上皮癌巢状变体的形态学和免疫组化比较
Am J Surg Pathol. 2003 Sep;27(9):1243-52. doi: 10.1097/00000478-200309000-00008.
10
Human Epidermal Growth Factor Receptor 2 Overexpression in Micropapillary and Other Variants of Urothelial Carcinoma.人表皮生长因子受体 2 在微乳头状和其他变异型尿路上皮癌中的过表达。
Eur Urol Focus. 2018 Apr;4(3):399-404. doi: 10.1016/j.euf.2016.06.007. Epub 2016 Jun 21.

引用本文的文献

1
Basaloid squamous cell carcinoma with prominent shadow (ghost) cell differentiation. An unreported neoplasm of the parotid gland.基底样鳞状细胞癌伴显著影细胞分化。一种未报道的腮腺肿瘤。
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):221-228. doi: 10.47162/RJME.63.1.25.
2
Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization.暗影细胞分化：细胞死亡模式与凋亡及表皮/外毛根鞘角化的比较分析
Dermatopathology (Basel). 2018 Jul 19;5(3):86-97. doi: 10.1159/000490491. eCollection 2018 Jul-Sep.
3
Shadow cell differentiation from squamoid morule in endometrial adenoacanthoma.子宫内膜腺棘皮瘤中鳞状小体向影细胞的分化。
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13120-4. eCollection 2015.
4
Ovarian basaloid carcinoma with shadow cell differentiation.伴有影细胞分化的卵巢基底样癌。
Case Rep Pathol. 2014;2014:391947. doi: 10.1155/2014/391947. Epub 2014 Feb 3.

本文引用的文献

1
Comparative immunohistochemical analyses on the modes of cell death/keratinization in epidermal cyst, trichilemmal cyst, and pilomatricoma.表皮囊肿、毛发上皮瘤和毛母质瘤细胞死亡/角化模式的比较免疫组化分析。
Am J Dermatopathol. 2011 Feb;33(1):78-83. doi: 10.1097/DAD.0b013e3181e3aec1.
2
The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma.毛母质瘤中β-连环蛋白表达的免疫组织化学模式
Ann Dermatol. 2010 Aug;22(3):284-9. doi: 10.5021/ad.2010.22.3.284. Epub 2010 Aug 5.
3
Cutaneous metastasis of ovarian carcinoma with shadow cells mimicking a primary pilomatrical neoplasm.伴有影细胞的卵巢癌皮肤转移，酷似原发性毛母质瘤。
Am J Dermatopathol. 2010 Jul;32(5):500-4. doi: 10.1097/DAD.0b013e3181c6dfc1.
4
beta-Catenin mutation and its nuclear localization are confirmed to be frequent causes of Wnt signaling pathway activation in pilomatricomas.β-连环蛋白突变及其核定位被证实是毛母质瘤中Wnt信号通路激活的常见原因。
J Dermatol Sci. 2006 Jan;41(1):67-75. doi: 10.1016/j.jdermsci.2005.09.005. Epub 2005 Dec 27.
5
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin.β-连环蛋白的关键作用：平衡细胞黏附与Wnt信号传导
Curr Opin Genet Dev. 2006 Feb;16(1):51-9. doi: 10.1016/j.gde.2005.12.007. Epub 2005 Dec 27.
6
Shadow cell differentiation in testicular teratomas. A report of two cases.
Cesk Patol. 2005 Jul;41(3):102-6.
7
beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst.β-连环蛋白在表达影子细胞的肿瘤中异常表达。如毛母质瘤、颅咽管瘤和牙源性钙化囊肿。
Am J Clin Pathol. 2003 Nov;120(5):732-6. doi: 10.1309/EALE-G7LD-6W71-67PX.
8
No evidence for involvement of beta-catenin and APC in urothelial carcinomas.没有证据表明β-连环蛋白和腺瘤性息肉病基因（APC）参与尿路上皮癌。
Int J Oncol. 2002 May;20(5):905-11.
9
Primary squamous cell carcinoma of the lung with pilomatricoma-like features.
Histopathology. 2002 Feb;40(2):201-2. doi: 10.1046/j.1365-2559.2002.1179b.x.
10
beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles.毛母质瘤中β-连环蛋白的表达。与β-连环蛋白基因突变的关系以及与正常毛囊中β-连环蛋白表达的比较。
Br J Dermatol. 2001 Oct;145(4):576-81. doi: 10.1046/j.1365-2133.2001.04455.x.

伴有影细胞分化的膀胱癌：一例免疫组化分析报告

Bladder carcinoma with shadow cell differentiation: a case report with immunohistochemical analyses.

作者信息

Nakamura Toshitsugu

机构信息

Department of Pathology, Suwa Red Cross Hospital Suwa, Japan.

出版信息

Int J Clin Exp Pathol. 2012;5(8):840-4. Epub 2012 Oct 1.

PMID:23071867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3466982/
Abstract

A peculiar case of bladder carcinoma showing shadow cell differentiation (SCD) in a 72-year-old man is presented. The tumor histologically revealed high grade urothelial carcinoma (UC) and partially contained squamous component with a transition to shadow cell nests, similar to those seen in cutaneous pilomatricoma (PMX). Immunohistochemically, the modes of cell death in the component of SCD were identical to those in PMX. The present case as well as 10 cases of cutaneous PMX showed nuclear expression of beta-catenin, whereas 10 cases of bladder UC with squamous differentiation revealed membranous localization without nuclear expression. These results suggest that nuclear accumulation of beta-catenin may play an important role for SCD in the present case. SCD in extracutaneous tumor is extremely rare and, in the literature, the present case is the second one as for bladder carcinoma.

摘要

本文报告了一例72岁男性膀胱移行细胞癌呈现影细胞分化（SCD）的特殊病例。肿瘤组织学检查显示为高级别尿路上皮癌（UC），部分包含鳞状成分，并过渡为影细胞巢，类似于皮肤毛母质瘤（PMX）所见。免疫组化显示，SCD成分中的细胞死亡模式与PMX相同。本病例以及10例皮肤PMX显示β-连环蛋白的核表达，而10例伴有鳞状分化的膀胱UC显示膜定位而无核表达。这些结果表明，β-连环蛋白的核积累可能在本病例的SCD中起重要作用。皮肤外肿瘤中的SCD极为罕见，在文献中，本病例是膀胱移行细胞癌的第二例。