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伴有影细胞分化的卵巢基底样癌。

Ovarian basaloid carcinoma with shadow cell differentiation.

作者信息

Zamecnik Michal, Jando Daniel, Kascak Peter

机构信息

Medicyt, s. r. o., Department of Surgical Pathology, Laboratory Trencin, Legionarska 28, 91171 Trencin, Slovakia ; Agel, a. s., Laboratory of Surgical Pathology, 74101 Novy Jicin, Czech Republic.

Department of Radiology, Faculty Hospital, 91171 Trencin, Slovakia.

出版信息

Case Rep Pathol. 2014;2014:391947. doi: 10.1155/2014/391947. Epub 2014 Feb 3.

DOI:10.1155/2014/391947
PMID:24639909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3929990/
Abstract

So-called shadow cell differentiation (SCD) is typical for pilomatrixoma and other skin lesions with follicular differentiation, but it was rarely described also in some visceral carcinomas. We report a case of ovarian basaloid carcinoma with SCD. The tumor presented as a 14 cm ovarian mass in a 45-year-old woman, and therefore the adnexectomy and hysterectomy were performed. The tumor was of high stage. Multiple metastases were found in the liver, retroperitoneal and mediastinal lymph nodes, and the lung. Histologically, the tumor showed a pattern of high-grade basaloid carcinoma with numerous shadow cells. Extensive histologic examination did not reveal any glandular or preexisting teratoma component. Immunohistochemically, the tumor expressed markers of squamous cell differentiation, such as p63, cytokeratin 5/6, and high-molecular-weight keratin. Cytokeratin 7 and CA125 were positive in scattered cells of the lesion. Estrogen and progesterone receptor, vimentin, and p53 were negative. Beta-catenin showed nuclear and cytoplasmic positivity, indicating possible tumor proliferation/differentiation via Wnt signaling pathway. To our knowledge, SCD in basaloid carcinoma of the ovary was not described before. In addition to the description of the case, we review the literature on SCD in visceral carcinomas.

摘要

所谓的影子细胞分化（SCD）是毛母质瘤和其他具有毛囊分化的皮肤病变的典型特征，但在一些内脏癌中也很少有描述。我们报告一例具有SCD的卵巢基底样癌病例。该肿瘤表现为一名45岁女性卵巢内一个14厘米的肿块，因此进行了附件切除术和子宫切除术。肿瘤分期较高。在肝脏、腹膜后和纵隔淋巴结以及肺部发现了多处转移。组织学上，肿瘤呈现高级别基底样癌的形态，有大量影子细胞。广泛的组织学检查未发现任何腺性或先前存在的畸胎瘤成分。免疫组化方面，肿瘤表达鳞状细胞分化标志物，如p63、细胞角蛋白5/6和高分子量角蛋白。细胞角蛋白7和CA125在病变的散在细胞中呈阳性。雌激素和孕激素受体、波形蛋白和p53均为阴性。β-连环蛋白显示细胞核和细胞质阳性，表明可能通过Wnt信号通路进行肿瘤增殖/分化。据我们所知，卵巢基底样癌中的SCD此前未见描述。除了该病例描述外，我们还回顾了关于内脏癌中SCD的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/96ae729a5025/CRIM.PATHOLOGY2014-391947.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/932d9c4d38d6/CRIM.PATHOLOGY2014-391947.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/f37eb4c6a653/CRIM.PATHOLOGY2014-391947.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/69abee9b9c40/CRIM.PATHOLOGY2014-391947.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/600d83b9e796/CRIM.PATHOLOGY2014-391947.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/7965f265e657/CRIM.PATHOLOGY2014-391947.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/5e266458b6fb/CRIM.PATHOLOGY2014-391947.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/96ae729a5025/CRIM.PATHOLOGY2014-391947.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/932d9c4d38d6/CRIM.PATHOLOGY2014-391947.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/f37eb4c6a653/CRIM.PATHOLOGY2014-391947.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/69abee9b9c40/CRIM.PATHOLOGY2014-391947.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/600d83b9e796/CRIM.PATHOLOGY2014-391947.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/7965f265e657/CRIM.PATHOLOGY2014-391947.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/5e266458b6fb/CRIM.PATHOLOGY2014-391947.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5807/3929990/96ae729a5025/CRIM.PATHOLOGY2014-391947.007.jpg

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