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人晶状体中的谷胱甘肽水平:不同类型白内障的区域分布

Glutathione levels in human lens: regional distribution in different forms of cataract.

作者信息

Pau H, Graf P, Sies H

机构信息

Department of Ophthalmology, University of Düsseldorf, F.R.G.

出版信息

Exp Eye Res. 1990 Jan;50(1):17-20. doi: 10.1016/0014-4835(90)90005-f.

DOI:10.1016/0014-4835(90)90005-f
PMID:2307192
Abstract

The content of glutathione is high in the anterior lens cortex (plus epithelium) and the posterior lens cortex, whereas it is substantially lower in the lens nucleus. A decrease of glutathione in the lens cortex does not occur with lenses from adults up to the highest age. The glutathione content is highest in the cortex of clear fresh lenses and shows a decrease with deep supranuclear cataract, primary nuclear cataract (cataracta brunescens nigra) and clear lenses post-mortem (approximately 20 hr). The subcapsular cataract, especially with additional secondary nuclear cataract, with cataracta matura or intumescens, shows a rapid and pronounced progressive decrease in the glutathione content.

摘要

谷胱甘肽的含量在前部晶状体皮质(加上皮)和后部晶状体皮质中较高,而在晶状体核中则显著较低。在成年直至最高年龄阶段的晶状体中,晶状体皮质中的谷胱甘肽含量不会降低。透明新鲜晶状体皮质中的谷胱甘肽含量最高,随着核上深层白内障、原发性核性白内障(黑色棕色白内障)以及死后(约20小时)的透明晶状体,其含量会降低。囊下白内障,尤其是伴有继发性核性白内障、成熟或肿胀性白内障时,谷胱甘肽含量会迅速且显著地逐渐降低。

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