前列腺素E在慢性肉芽肿性炎症中的分布及其活性的进一步研究。

Distribution and further studies on the activity of prostaglandin E in chronic granulomatous inflammation.

作者信息

Bonta I L, Adolfs M J, Parnham M J

出版信息

Agents Actions Suppl. 1979(6):121-32. doi: 10.1007/978-3-0348-7232-4_14.

Abstract

Pre-formed granulomata, induced by cannulated, carrageenin-soaked, subdermal sponge implants, were used to further analyse the effects of exogenous PGE and the involvement of endogenous PGE in this model of chronic inflammatory tissue changes in rats. Experiments with 14C-PGE2 indicated that administration of PGE into the sponge creates a kinetic situation likely to imitate, but superimposed upon, the continuous discharge of endogenous PGE in the granuloma. The granuloma-reducing, anti-flammatory effect of PGE can be mimicked by dibutyryl cyclic-AMP, phosphodiesterase inhibitors and indomethacin. Most probably these compounds, in common with PGE, exert their anti-granuloma action through elevation of intracellular cyclic-AMP (in macrophages and/or fibroblasts). The anti-granuloma action is not necessarily associated with a reduction in the endogenous PGE-level and vice versa. The involvement of endogenous PGE in the tissue events of granulomatous inflammation is conjectural as yet.

摘要

通过皮下植入插管并用角叉菜胶浸泡的海绵诱导形成的预先存在的肉芽肿，被用于进一步分析外源性前列腺素E（PGE）的作用以及内源性PGE在大鼠慢性炎症组织变化模型中的参与情况。用14C-PGE2进行的实验表明，将PGE注入海绵中会产生一种动力学情况，可能类似于但叠加在肉芽肿中内源性PGE的持续释放之上。PGE的肉芽肿减少抗炎作用可被二丁酰环磷腺苷、磷酸二酯酶抑制剂和吲哚美辛模拟。很可能这些化合物与PGE一样，通过提高细胞内环磷腺苷（在巨噬细胞和/或成纤维细胞中）发挥其抗肉芽肿作用。抗肉芽肿作用不一定与内源性PGE水平的降低相关，反之亦然。内源性PGE在肉芽肿性炎症的组织事件中的参与情况目前仍属推测。