Nutrition, Gut & Brain Unit, INSERM UMR 1073, Institute for Biomedical Research and Innovation, Rouen University, Rouen, France.
Eur J Gastroenterol Hepatol. 2013 Feb;25(2):213-7. doi: 10.1097/MEG.0b013e32835a7f04.
Gastric electrical stimulation (GES) is now considered as a new therapeutic alternative for patients with medically refractory vomiting and/or nausea, although its mechanisms of action remain poorly understood.
Gastric discomfort threshold, measured as the gastric maximal tolerable volume (MTV) to distension, was examined before and after GES, in nine patients implanted for chronic and severe nausea and vomiting.
GES increased gastric MTV from 522 ± 64 ml at baseline to 628 ± 60 ml 6 months after the start of GES (P=0.03), whereas gastric emptying remained unchanged. The increase in MTV was correlated with symptoms and quality of life at 6 months, whereas gastric emptying was not. Finally, MTV varied in a similar manner at 6 months in patients with delayed and normal gastric emptying measured before implantation.
Taken together, these data indicate that modification of gastric sensation to distension, rather than gastric emptying, is associated with symptoms' outcome during GES.
胃电刺激（GES）现在被认为是一种治疗药物难治性呕吐和/或恶心的新方法，尽管其作用机制仍不清楚。
在 9 名因慢性和严重恶心和呕吐而植入 GES 的患者中，检查了胃电刺激前后胃不适阈值，即胃扩张的最大耐受容量（MTV）。
GES 使 MTV 从基线时的 522±64ml 增加到 GES 开始后 6 个月时的 628±60ml（P=0.03），而胃排空保持不变。6 个月时 MTV 的增加与症状和生活质量相关，而胃排空则没有。最后，在植入前测量胃排空延迟和正常的患者中，6 个月时 MTV 以相似的方式变化。
综上所述，这些数据表明，胃扩张感觉的改变，而不是胃排空，与 GES 期间症状的结果相关。
