School of Mechanical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, Korea.
Clin Hemorheol Microcirc. 2013;55(3):341-8. doi: 10.3233/CH-2012-1641.
Lead is a ubiquitous, biohazardous, and toxic heavy metal that induces a broad range of physiological, biochemical, and behavioral dysfunctions. We investigated the effect of lead on hemorheological characteristics, including deformability and aggregation. We found that red blood cell (RBC) deformability was unaffected at low concentrations of lead-rich plasma, but showed a significant decrease at high concentrations even within 1 h of incubation. In addition, apparent alterations in RBC aggregation were observed with an increase in lead concentration and incubation time. These results highlight the influence of lead on hemorheology and microcirculation.
铅是一种普遍存在的、对生物有害的有毒重金属，它会引起广泛的生理、生化和行为功能障碍。我们研究了铅对血液流变学特性的影响，包括变形性和聚集性。我们发现，低浓度富铅血浆中的红细胞（RBC）变形性不受影响，但在孵育 1 小时内高浓度下则显著降低。此外，随着铅浓度和孵育时间的增加，RBC 聚集的明显变化也被观察到。这些结果强调了铅对血液流变学和微循环的影响。
