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基于纳米马达的血液铅（II）去除吸附剂及其在猪模型中的应用

Nanomotor-based adsorbent for blood Lead(II) removal and in pig models.

作者信息

Wang Meng, Bao Tianyi, Yan Wenqiang, Fang Dan, Yu Yueqi, Liu Zhiyong, Yin Guoyong, Wan Mimi, Mao Chun, Shi Dongquan

机构信息

National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China.

Department of Orthopaedics the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, PR China.

出版信息

Bioact Mater. 2020 Oct 23;6(4):1140-1149. doi: 10.1016/j.bioactmat.2020.09.032. eCollection 2021 Apr.

DOI:10.1016/j.bioactmat.2020.09.032
PMID:33134607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7588752/
Abstract

Blood lead (Pb(II)) removal is very important but challenging. The main difficulty of blood Pb(II) removal currently lies in the fact that blood Pb(II) is mainly complexed with hemoglobin (Hb) inside the red blood cells (RBCs). Traditional blood Pb(II) removers are mostly passive particles that do not have the motion ability, thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively low. Herein, a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on FeO nanoparticle modified with meso-2, 3-dimercaptosuccinic acid (DMSA) was prepared and a blood Pb(II) removal strategy was further proposed. During the removal process, the nanomotor adsorbent can enter the RBCs, then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of nanomotor. Through the strong coordination of functional groups in DMSA, the nanomotor adsorbent can adsorb Pb(II), and finally be separated from blood by permanent magnetic field. The extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II) in pig models, which may provide innovative ideas for blood heavy metal removal in the future.

摘要

去除血液中的铅（Pb(II)）非常重要但具有挑战性。目前去除血液中Pb(II)的主要困难在于，血液中的Pb(II)主要与红细胞（RBC）内的血红蛋白（Hb）络合。传统的血液Pb(II)去除剂大多是没有运动能力的被动颗粒，因此吸附剂与受Pb(II)污染的Hb之间的接触效率相对较低。在此，制备了一种基于用中-2,3-二巯基琥珀酸（DMSA）修饰的FeO纳米颗粒的在交变磁场下具有运动能力的磁性纳米马达吸附剂，并进一步提出了一种去除血液中Pb(II)的策略。在去除过程中，纳米马达吸附剂可以进入RBC，然后通过纳米马达的主动运动增加纳米马达吸附剂与受Pb(II)污染的Hb之间的接触概率。通过DMSA中官能团的强配位作用，纳米马达吸附剂可以吸附Pb(II)，最后通过永久磁场与血液分离。体外血液循环实验验证了该吸附剂在猪模型中去除血液中Pb(II)的能力，这可能为未来血液重金属去除提供创新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/dcdcf9c8a994/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/2497c66c2212/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/e4fcbecf97ab/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/f07813e98125/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/32659e9236fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/3d5d79f0a096/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/70f91341335b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/dcdcf9c8a994/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/2497c66c2212/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/e4fcbecf97ab/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/f07813e98125/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/32659e9236fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/3d5d79f0a096/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/70f91341335b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e28/7588752/dcdcf9c8a994/gr6.jpg

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