Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Tohoku J Exp Med. 2012 Nov;228(3):205-14. doi: 10.1620/tjem.228.205.
Low birth weight has been associated with cardiovascular diseases. The waist-to-height ratio is a good indicator of risks for these diseases. The objective of this study was to examine the associations between birth weight and adult waist-to-height ratio in a Japanese population. A cross-sectional study, comprised of 851 subjects (401 men and 450 women) aged 35-62 years who were born at full term, was conducted at a medical checkup. The subjects responded to a questionnaire about weight at birth, and data on physical characteristics were collected from the results of the medical checkup. The subjects were stratified with sex and a Body Mass Index of 25 kg/m(2) to elucidate the effects of birth weight on adult waist-to-height ratio. Analysis of covariance was used to compare the physical condition among the 4 birth weight categories. After adjusting for age, alcohol consumption, smoking status and exercise, the height was significantly lower in the birth weight < 2,500 g category among men (P < 0.001) and women (P < 0.001), while the waist-to-height ratio was significantly higher in the birth weight < 2,500 g category, compared with the > 3,500 g category in the non-obese women (P = 0.004), but not in the obese women. In conclusion, low birth weight was independently associated with a low adult height among men and women and with a high adult waist-to-height ratio among non-obese women. Our results suggest that intrauterine environmental insults might lead to accumulation of visceral fat among non-obese women.
低出生体重与心血管疾病有关。腰高比是这些疾病风险的一个很好的指标。本研究的目的是在日本人群中检查出生体重与成人腰高比之间的关系。一项横断面研究包括 851 名（401 名男性和 450 名女性）年龄在 35-62 岁的足月出生的受试者，在体检时进行。受试者对出生时的体重进行了问卷调查，并从体检结果中收集了身体特征数据。根据性别和身体质量指数 25kg/m(2)将受试者分层，以阐明出生体重对成人腰高比的影响。使用协方差分析比较 4 个出生体重组之间的身体状况。在校正年龄、饮酒、吸烟状况和运动后，在男性（P<0.001）和女性（P<0.001）中，出生体重<2500g 组的身高明显较低，而在非肥胖女性中，出生体重<2500g 组的腰高比明显高于>3500g 组（P=0.004），但在肥胖女性中则不然。总之，低出生体重与男性和女性的成年身高较低以及非肥胖女性的成年腰高比较高独立相关。我们的结果表明，宫内环境损伤可能导致非肥胖女性内脏脂肪堆积。
