Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark.
Aust N Z J Psychiatry. 2013 Mar;47(3):250-8. doi: 10.1177/0004867412463614. Epub 2012 Oct 16.
People with psychiatric diseases have a severely increased risk for physical morbidity and premature death from physical diseases. The aims of the study were to investigate the occurrence of cardiovascular diseases (CVD), diabetes (DM) and obesity in schizophrenia and depression in three different geographical areas - Asia (Japan), Africa (Nigeria) and Western Europe (Switzerland, Germany and Denmark) - and to search for possible transcultural differences in these correlations, which would also reflect the differences between low-income areas in Africa (Nigeria) and high-income areas in Europe and Japan.
Patients with International Classification of Diseases (ICD-10) F2 diseases (schizophrenia spectrum disorders) and F3 diseases (affective disorders) admitted to one Nigerian, one Japanese, two Swiss, two German and six Danish centres during 1 year were included. Physical diseases in accordance with ICD-10 were also registered. Psychiatric and physical comorbidity were calculated and standardized rate ratio incidences of background populations were our primary measures.
Incidence rate ratios were increased for both CVD, DM and overweight in both F2 and F3 in all cultures (Western Europe, Nigeria and Japan) within the same ranges (however, the Japanese results should be interpreted conservatively owing to the limited sample size). Overweight among the mentally ill were marked in Nigeria. A parallelism of the incidence of overweight, CVD and diabetes with the occurrence in background populations was seen and was most marked in overweight.
Overweight, CVD and DM were increased in schizophrenia spectrum disorders and affective disorders in all three cultures investigated (Western Europe, Nigeria and Japan). Lifestyle diseases were also seen in Nigeria and Japan. The results from this study indicate that cultural background might be seen as an important factor in dealing with lifestyle diseases among people with a severe mental illness, as it is in the general population.
精神疾病患者罹患躯体疾病和因躯体疾病而过早死亡的风险严重增加。本研究旨在调查在三个不同地理区域(亚洲[日本]、非洲[尼日利亚]和西欧[瑞士、德国和丹麦])的精神分裂症和抑郁症患者中心血管疾病(CVD)、糖尿病(DM)和肥胖症的发生情况,并寻找这些相关性中可能存在的跨文化差异,这些差异也反映了非洲(尼日利亚)低收入地区与欧洲和日本高收入地区之间的差异。
纳入在一年内因国际疾病分类第 10 版(F2 疾病:精神分裂症谱系障碍;F3 疾病:情感障碍)入住一家尼日利亚、一家日本、两家瑞士、两家德国和六家丹麦中心的患者。还按 ICD-10 登记了躯体疾病。计算了精神和躯体共病情况,并将背景人群的标准化发病比作为主要指标。
在所有文化中(西欧、尼日利亚和日本),F2 和 F3 患者的 CVD、DM 和超重发生率均升高(然而,鉴于样本量有限,日本的结果应谨慎解释)。尼日利亚精神疾病患者的超重情况明显。精神疾病患者超重、CVD 和糖尿病的发病率与背景人群的发病率平行,且超重最为明显。
在本研究调查的所有三种文化(西欧、尼日利亚和日本)中,精神分裂症谱系障碍和情感障碍患者中超重、CVD 和 DM 增加。在尼日利亚和日本也观察到生活方式疾病。本研究结果表明,文化背景可能被视为严重精神疾病患者处理生活方式疾病的一个重要因素,正如在一般人群中一样。