Kalfas S, Svensäter G, Birkhed D, Edwardsson S
Department of Oral Microbiology, University of Lund, School of Dentistry, Malmö, Sweden.
J Dent Res. 1990 Feb;69(2):442-6. doi: 10.1177/00220345900690020401.
Caries-related bacteriological and biochemical factors were studied in 12 persons with low and 11 persons with normal salivary-secretion rates before and after a four-week period of frequent mouthrinses with 10% sorbitol solution (adaptation period). After the adaptation period, an increase in total numbers of sorbitol-fermenting bacteria and mutans streptococci was found in plaque samples from both groups. The pH drop in dental plaque in situ after a mouthrinse with sorbitol was more pronounced after the adaptation period, especially in the group with the low salivary-secretion rate. Increased acid production in plaque from sorbitol was also observed in the two groups in vitro. The composition of the fermentation end-products was affected by the sorbitol exposure. It is suggested that in subjects with diminished natural protection against caries development, such as patients with low salivary-secretion rate, a cariogenic potential of sorbitol should be considered when this polyol is included in products that might be used frequently.
在12名唾液分泌率低的人和11名唾液分泌率正常的人身上，研究了与龋齿相关的细菌学和生化因素。在使用10%山梨醇溶液频繁漱口四周（适应期）前后进行了研究。适应期后，两组菌斑样本中发酵山梨醇的细菌和变形链球菌总数均有所增加。适应期后，用山梨醇漱口后牙菌斑原位的pH值下降更为明显，尤其是在唾液分泌率低的组中。在体外，两组菌斑中由山梨醇产生的酸也有所增加。发酵终产物的组成受山梨醇暴露的影响。建议在对龋齿发展天然保护能力减弱的受试者中，如唾液分泌率低的患者，当这种多元醇被包含在可能经常使用的产品中时，应考虑山梨醇的致龋潜力。
