Department of Molecular Medicine, Unit of Occupational Medicine, University of Padua.
Med Lav. 2012 Sep-Oct;103(5):382-93.
Perchloroethylene (PCE) is the most widely used solvent in dry cleaning.
The aim was to evaluate PCE pollution and to identify the most reliable biological indicators for the assessment of workers' exposure.
The study was performed in 40 dry cleaning shops covering a total of 71 subjects. Environmental monitoring was carried out with personal diffusive samplers (Radiello) for the entire work shift; biological monitoring was performed by measuring PCE in urine and blood and trichloroacetic acid (TCA) in urine on Thursday evening at end-of shift and on Friday morning pre-shift.
The mean concentration of PCE in air was 52.32 mg/m3, about 30% of the TLV-TWA and the mean value of the PCE inpre-shift blood samples was 0.304 mg/l, slightly more than 50% of the BEI. In dry cleaning shops employing less than 3 persons PCE in air exceeded the TLV-TWA in 7.8% of cases; the size of the shops was inversely related to pollution. Statistically significant correlations were found between PCE exposure and PCE in blood end-of-shift (r = 0.67) and pre-shift (r = 0.70), and PCE in urine end-of-shift (r = 0.68); no correlation was found between exposure and PCE in urine pre-shift and urinary TCA.
Dry cleaning shops still register conditions of exposure and pollution by PCE, although to a lesser extent than in the past. The most reliable indicators for biological monitoring are CE in end-of-shift urine and PCE in blood both at end-of-shift and pre-shift at the end of the workweek.
全氯乙烯（PCE）是干洗中使用最广泛的溶剂。
评估 PCE 污染情况，并确定评估工人暴露最可靠的生物标志物。
该研究在 40 家干洗店进行，共涉及 71 名研究对象。整个工作班次均使用个人扩散采样器（Radiello）进行环境监测；生物监测通过测量周四晚间下班时和周五上班前的尿液和血液中的 PCE 以及尿液中的三氯乙酸（TCA）来进行。
空气中 PCE 的平均浓度为 52.32mg/m3，约为 TLV-TWA 的 30%，班前血样中 PCE 的平均值为 0.304mg/L，略高于 BEI 的 50%。在使用人数少于 3 人的干洗店中，7.8%的情况下空气中的 PCE 超过了 TLV-TWA；干洗店的规模与污染程度呈反比。暴露于 PCE 与下班时血液中的 PCE（r=0.67）和班前（r=0.70）以及下班时尿液中的 PCE（r=0.68）之间存在显著的相关性，但与班前尿液中的 PCE 和尿液中的 TCA 之间无相关性。
尽管干洗店的 PCE 暴露和污染程度比过去有所减轻，但仍存在暴露和污染情况。生物监测最可靠的标志物是下班时尿液中的 PCE 和班前及下班时血液中的 PCE。
