不同辐射敏感性的细胞成分在胸腺中诱导的克隆清除和克隆无能。
Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
作者信息
Roberts J L, Sharrow S O, Singer A
机构信息
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1990 Mar 1;171(3):935-40. doi: 10.1084/jem.171.3.935.
Abstract
The present study demonstrates that immune tolerance can be achieved in the thymus both by clonal deletion and by clonal inactivation, but that the two tolerant states are induced by cellular elements with different radiation sensitivities. TCR engagement of self antigens on bone marrow-derived, radiation-sensitive (presumably dendritic) cells induces clonal deletion of developing thymocytes, whereas TCR engagement of self antigens on radiation-resistant cellular elements, such as thymic epithelium, induces clonal anergy. The nondeleted, anergic thymocytes can express IL-2-Rs but are unable to proliferate in response to either specific antigen or anti-TCR antibodies, and do develop into phenotypically mature cells that emigrate out of the thymus and into the periphery.
摘要
本研究表明，免疫耐受可在胸腺中通过克隆清除和克隆失活来实现，但这两种耐受状态是由具有不同辐射敏感性的细胞成分诱导产生的。骨髓来源的、辐射敏感的（可能是树突状）细胞上自身抗原的TCR结合诱导发育中的胸腺细胞克隆清除，而辐射抗性细胞成分（如胸腺上皮）上自身抗原的TCR结合诱导克隆无能。未被清除的无能胸腺细胞可表达IL-2受体，但无法对特异性抗原或抗TCR抗体作出增殖反应，并且确实发育为表型成熟的细胞，这些细胞迁出胸腺进入外周。
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