Fiorica V M, Albers D D, Tu Y H, Allen L V
University of Oklahoma, Health Sciences Center, College of Pharmacy.
J Okla State Med Assoc. 1990 Jan;83(1):15-7.
A rat model for determining drug levels in the seminal vesicle was developed. In separate studies, trimethoprim and metronidazole were injected intravenously into rats and assays of seminal vesicle, plasma, and prostate performed. Drug levels were detected early in both the seminal vesicle and prostate. This appears to be the first study to report drug levels in the seminal vesicle. Metronidazole levels in the seminal vesicle were very low and short lived.
建立了一种用于测定精囊内药物水平的大鼠模型。在单独的研究中，将甲氧苄啶和甲硝唑静脉注射到大鼠体内，并对精囊、血浆和前列腺进行检测。在精囊和前列腺中均早期检测到药物水平。这似乎是第一项报告精囊内药物水平的研究。精囊内的甲硝唑水平非常低且持续时间短。
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