Kempinas W G, Lamano-Carvalho T L, Petenusci S O, Favaretto A L, Lopes R A, Azoubel R
Faculty of Dentistry of Ribeirão Preto, USP, Brazil.
Gegenbaurs Morphol Jahrb. 1988;134(5):791-8.
In order to investigate the effects of chronic lead intoxication on sexual accessory glands adult male Wistar rats were poisoned by ad libitum ingestion of lead acetate at concentrations of 0.5 g/l and 1.0 g/l for 90 d. Blood lead exhibited a significant increase in both treated groups. A decrease in hematocrit and hemoglobin, besides a rise in glycemic levels, confirmed lead intoxication. No sign of lesion was detected upon histologic examination of prostate, seminal vesicle, and coagulating gland. A morphometric technique revealed that, in this early phase of intoxication, no alteration occurred in the prostate's and seminal vesicle's epithelial height. However, a significant decrease in fructose content was observed in both lead treated groups. The results, revealing a precocious envolvement of male sexual accessory glands in lead intoxication, were related to disturbance in plasma testosterone level and also probably in androgen receptors.
为了研究慢性铅中毒对雄性附属性腺的影响，将成年雄性Wistar大鼠自由饮用浓度为0.5 g/l和1.0 g/l的醋酸铅溶液90天进行中毒处理。两个处理组的血铅水平均显著升高。血细胞比容和血红蛋白降低，血糖水平升高，证实发生了铅中毒。对前列腺、精囊和凝固腺进行组织学检查未发现病变迹象。形态计量学技术显示，在中毒早期，前列腺和精囊的上皮高度没有改变。然而，两个铅处理组的果糖含量均显著降低。结果表明，雄性附属性腺在铅中毒早期就受到影响，这与血浆睾酮水平以及可能的雄激素受体紊乱有关。
