Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
Prenat Diagn. 2012 Dec;32(13):1273-81. doi: 10.1002/pd.3992. Epub 2012 Oct 18.
To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV.
This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fissure (CF) and sylvian fissure, and grading the Sylvian fissure operculization at 23-25, 27-28 and 31-32 weeks gestation were determined.
At 23-25 and 27-28 gestational weeks, POF and CF mean depths were statistically lower in the IMV group. The POF and CF depth distribution had a normal distribution in the control group but displayed a bimodal distribution in the IMV group. IMV with progression of ventricular dilatation showed mean depth of CF lower than IMV in which ventriculomegaly regressed or remained stable. The sensitivity, specificity, positive predictive value and negative predictive value of a CF depth below the fifth percentile to predict progression of ventricular dilatation were, at 28 weeks, 100%, 88%, 67% and 100%, respectively.
Cortical fissure assessment by ultrasound allowed the differentiation of a subgroup of IMV fetuses with a higher risk of progression of ventricular dilatation.
比较单纯性脑室扩大（IMV）胎儿与正常胎儿的皮质成熟度，并探讨其在 IMV 中的潜在预后价值。
本前瞻性研究对 24 例 IMV 胎儿和 46 例正常胎儿进行了超声皮质成熟度定量分析。在 23-25 周、27-28 周和 31-32 周时，评估顶枕裂（POF）、距状裂（CF）和大脑外侧裂的发育模式深度和分级，以及大脑外侧裂盖的分级。
在 23-25 周和 27-28 周时，IMV 组的 POF 和 CF 平均深度明显较低。对照组 POF 和 CF 深度分布呈正态分布，而 IMV 组呈双峰分布。伴有脑室扩张进展的 IMV 其 CF 深度低于脑室扩张消退或保持稳定的 IMV。在 28 周时，CF 深度低于第 5 百分位预测脑室扩张进展的敏感性、特异性、阳性预测值和阴性预测值分别为 100%、88%、67%和 100%。
超声评估皮质裂可以区分出具有更高脑室扩张进展风险的 IMV 胎儿亚组。
