Turfan Murat, Erdogan Ercan, Ertas Gökhan, Duran Mustafa, Murat Sani Namk, Celik Etem, Baydar Caner, Tasal Abdurrahman, Vatankulu Mehmet A, Sevgili Emrah, Kul Seref, Yoldas Tahir, Goktekin Omer
Bezmialem University, Faculty of Medicine, Department of Cardiology, Istanbul, Turkey.
Blood Coagul Fibrinolysis. 2013 Jan;24(1):55-8. doi: 10.1097/MBC.0b013e32835a0850.
Early detection of atrial fibrillation patients at high risk for stroke is important. There are some studies which indicate that mean platelet volume (MPV) determines the prognosis and risk in patients with a stroke. In this study, our aim was to investigate the association between the MPV measured in stroke patients with atrial fibrillation. Consecutive patients referred to our center between January 2010 and April 2012 were included in this study. The patients with atrial fibrillation were classified into two groups according to presence or absence of a history of stroke by combining data from the medical histories after a thorough review of the medical records. MPV determination was made within 24 h following the onset of stroke. We studied 63 consecutive stroke patients with atrial fibrillation and 77 atrial fibrillation patients without stroke history. In receiver-operating characteristic (ROC) curve analysis, the value for MPV levels to detect stroke with a sensitivity of 63.5% and specificity of 64.4% was 9.4 fl. High MPV (>9.4 fl) was significantly associated with the occurrence of stroke [odds ratio (OR) 4.021, 95% confidence interval (CI) 1709-9464, P < 0.001]. Our study supports the hypothesis that a high MPV is associated with an increased risk of stroke in atrial fibrillation patients.
早期发现有高卒中风险的房颤患者很重要。有一些研究表明，平均血小板体积（MPV）决定了卒中患者的预后和风险。在本研究中，我们的目的是调查房颤卒中患者中所测MPV之间的关联。2010年1月至2012年4月转诊至我们中心的连续患者被纳入本研究。通过全面查阅病历并结合病史数据，将房颤患者根据有无卒中史分为两组。在卒中发作后24小时内测定MPV。我们研究了63例连续的房颤卒中患者和77例无卒中史的房颤患者。在受试者工作特征（ROC）曲线分析中，MPV水平检测卒中的灵敏度为63.5%、特异度为64.4%时的值为9.4飞升。高MPV（>9.4飞升）与卒中的发生显著相关[比值比（OR）4.021，95%置信区间（CI）1709 - 9464，P < 0.001]。我们的研究支持高MPV与房颤患者卒中风险增加相关这一假说。
