Özkan Buğra, Arik Osman Z, Gözükara Mehmet Y, Şahin Durmuş Y, Topal Salih, Uysal Onur K, Elbasan Zafer, Epçeliden Tuncay, Çayli Murat, Gür Mustafa
aDepartment of Cardiology, Bucak State Hospital, Burdur bDepartment of Cardiology, Gümüşhane State Hospital, Gümüşhane cDepartment of Internal Medicine, Mersin State Hospital, Mersin dDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana eDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara fDepartment of Cardiology, Kayseri Training and Research Hospital, Kayseri and gDepartment of Neurology, Bucak State Hospital, Burdur Turkey.
Blood Coagul Fibrinolysis. 2016 Jul;27(5):490-3. doi: 10.1097/MBC.0000000000000108.
Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with sinus rhythm. We evaluated 74 patients in sinus rhythm and with ischemic stroke (Group 1) and 90 age-matched and sex-matched healthy individuals as control group (Group 2). After physical and echocardiographic examination, 24-48 h Holter monitoring and complete blood counts were studied. There were no statistically significant differences in age, sex rates, and comorbidities between groups. Left atrial diameter was higher in Group 1 than Group 2 (P = 0.001), but both were in normal range. MPV was significantly higher in Group 1 (P < 0.001) and was an independent determinant [odds ratio (OR): 1.840; P < 0.001; 95% confidence interval (CI) 1.330-2.545] of ischemic stroke with left atrial (OR: 1.138; P = 0.006; 95% CI 1.037-1.248). In conclusion, higher MPV is associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement. MPV and left atrial diameter are independent predictors of ischemic stroke in this patient population.
中风是全球残疾的主要原因。已知心房颤动和左心房增大易引发缺血性中风，且缺血性中风和心房颤动患者的平均血小板体积（MPV）会增加。我们旨在确定较高的MPV是否与窦性心律患者的缺血性中风相关。我们评估了74例窦性心律且患有缺血性中风的患者（第1组）以及90例年龄和性别匹配的健康个体作为对照组（第2组）。在进行体格检查和超声心动图检查后，进行了24 - 48小时的动态心电图监测和全血细胞计数研究。两组之间在年龄、性别比例和合并症方面无统计学显著差异。第1组的左心房直径高于第2组（P = 0.001），但两者均在正常范围内。第1组的MPV显著更高（P < 0.001），并且是缺血性中风的独立决定因素[比值比（OR）：1.840；P < 0.001；95%置信区间（CI）1.330 - 2.545]，左心房也是缺血性中风的独立决定因素（OR：1.138；P = 0.006；95% CI 1.037 - 1.248）。总之，较高的MPV与无心力衰竭或左心房增大的窦性心律患者的急性缺血性中风相关。在该患者群体中，MPV和左心房直径是缺血性中风的独立预测因素。
