Cobanoglu H Bengü, Constantinides Minas, Ural Ahmet
Department of Otorhinolaryngology, Kanuni Education and Research Hospital, Trabzon, Turkey.
Facial Plast Surg Clin North Am. 2012 Nov;20(4):437-43. doi: 10.1016/j.fsc.2012.07.006.
Histopathologic examination is the gold standard for the diagnosis of skin cancer. Because analysis of molecular parameters such as nucleic acids and DNA are also gaining importance in diagnosis, prognosis, and therapy, an understanding of the molecular mechanisms underlying the pathogenesis of nonmelanoma skin cancer of the head and neck is of growing importance for the diagnostician and surgeon alike. This article presents a description of the effect on cells and impact on DNA of ultraviolet radiation, with a discussion of squamous cell and basal cell carcinoma in terms of the effects of genetic pathways and apoptosis.
组织病理学检查是皮肤癌诊断的金标准。由于对核酸和DNA等分子参数的分析在诊断、预后和治疗中也日益重要，因此对于头颈非黑色素瘤皮肤癌发病机制的分子机制的理解，对于诊断医生和外科医生来说都愈发重要。本文描述了紫外线辐射对细胞的影响及其对DNA的作用，并从遗传途径和细胞凋亡的影响方面讨论了鳞状细胞癌和基底细胞癌。
