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Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

作者信息

De Clercq E, Descamps J, Schmidt C L, Mertes M P

出版信息

Biochem Pharmacol. 1979 Nov 15;28(22):3249-54. doi: 10.1016/0006-2952(79)90117-5.

DOI:10.1016/0006-2952(79)90117-5
PMID:230848
Abstract
摘要

相似文献

1
Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.5-甲硫基甲基-2'-脱氧尿苷及其他5-取代2'-脱氧尿苷的抗病毒活性
Biochem Pharmacol. 1979 Nov 15;28(22):3249-54. doi: 10.1016/0006-2952(79)90117-5.
2
5-Substituted 2'-deoxyuridines which selectively inhibit herpes simplex virus replication.选择性抑制单纯疱疹病毒复制的5-取代2'-脱氧尿苷。
Adv Ophthalmol. 1979;38:204-13.
3
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.5 -（5 - 溴噻吩 - 2 - 基）- 2'-脱氧尿苷和5 -（5 - 氯噻吩 - 2 - 基）- 2'-脱氧尿苷在抑制单纯疱疹病毒I型复制方面与（E）- 5 -（2 - 溴乙烯基）- 2'-脱氧尿苷具有同等效力。
J Med Chem. 1991 Aug;34(8):2383-9. doi: 10.1021/jm00112a011.
4
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.5-羟基-2'-脱氧尿苷的5-O-烷基化衍生物作为潜在的抗病毒剂。5-丙炔氧基-2'-脱氧尿苷的抗疱疹活性。
J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018.
5
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.5-氰基尿苷和5-氰基-2'-脱氧尿苷的合成改进及其体外抗病毒活性
J Med Chem. 1977 Jul;20(7):974-6. doi: 10.1021/jm00217a026.
6
Synthesis and biological activity of 5-(2,2-difluorocyclopropyl)-2'-deoxyuridine deoxyuridine diastereomers.
Drug Des Discov. 1992;9(1):79-91.
7
Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.单纯疱疹病毒近期临床分离株对5-乙基-2'-脱氧尿苷的敏感性：对2型单纯疱疹病毒的优先抑制作用
Antimicrob Agents Chemother. 1983 May;23(5):637-40. doi: 10.1128/AAC.23.5.637.
8
Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.脱氧尿苷的汞硫类似物对1型和2型单纯疱疹病毒体外复制的抑制作用
Antiviral Res. 1991 Sep;16(2):197-203. doi: 10.1016/0166-3542(91)90025-m.
9
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.5-[(甲硫基)甲基]-2'-脱氧尿苷、相应的亚砜和砜及其5'-磷酸酯的合成：抗病毒作用及胸苷酸合成酶抑制作用
J Med Chem. 1980 Mar;23(3):252-6. doi: 10.1021/jm00177a008.
10
Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates.
Biochem Pharmacol. 1981 Mar 1;30(5):495-502. doi: 10.1016/0006-2952(81)90635-3.

引用本文的文献

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Antiviral nucleoside analogs.抗病毒核苷类似物。
Chem Heterocycl Compd (N Y). 2021;57(4):326-341. doi: 10.1007/s10593-021-02912-8. Epub 2021 May 14.
2
Historical perspectives in the development of antiviral agents against poxviruses.抗痘病毒药物的发展历史。
Viruses. 2010 Jun;2(6):1322-1339. doi: 10.3390/v2061322. Epub 2010 Jun 14.
3
Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.抗疱疹嘧啶和嘌呤核苷类似物的构效关系及构象特征。综述。
Pharm World Sci. 1994 Apr 15;16(2):127-38. doi: 10.1007/BF01880663.
4
Thymidylate synthetase-deficient mouse FM3A mammary carcinoma cell line as a tool for studying the thymidine salvage pathway and the incorporation of thymidine analogues into host cell DNA.胸苷酸合成酶缺陷型小鼠FM3A乳腺癌细胞系作为研究胸苷补救途径以及胸苷类似物掺入宿主细胞DNA的工具。
Biochem J. 1984 Jan 1;217(1):245-52. doi: 10.1042/bj2170245.
5
Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.在细胞培养中对胸腺嘧啶核苷逆转核苷类似物抗疱疹活性的动力学分析。
Antimicrob Agents Chemother. 1983 Nov;24(5):819-22. doi: 10.1128/AAC.24.5.819.