• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.单纯疱疹病毒近期临床分离株对5-乙基-2'-脱氧尿苷的敏感性：对2型单纯疱疹病毒的优先抑制作用
Antimicrob Agents Chemother. 1983 May;23(5):637-40. doi: 10.1128/AAC.23.5.637.
2
Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs.5-乙基-2'-脱氧尿苷在细胞培养、小鼠和豚鼠中对单纯疱疹病毒的抗病毒活性。
Antimicrob Agents Chemother. 1985 Oct;28(4):552-60. doi: 10.1128/AAC.28.4.552.
3
Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.脱氧尿苷的汞硫类似物对1型和2型单纯疱疹病毒体外复制的抑制作用
Antiviral Res. 1991 Sep;16(2):197-203. doi: 10.1016/0166-3542(91)90025-m.
4
Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.5-(2-卤代烷基)嘧啶核苷类似物，特别是5-(2-氯乙基)-2'-脱氧尿苷对单纯疱疹病毒的体外和体内选择性活性。
Antimicrob Agents Chemother. 1985 Aug;28(2):246-51. doi: 10.1128/AAC.28.2.246.
5
Evaluation of three methods for typing herpes simplex virus.三种单纯疱疹病毒分型方法的评估
Eur J Clin Microbiol. 1987 Dec;6(6):664-7. doi: 10.1007/BF02013066.
6
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.5-羟基-2'-脱氧尿苷的5-O-烷基化衍生物作为潜在的抗病毒剂。5-丙炔氧基-2'-脱氧尿苷的抗疱疹活性。
J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018.
7
Identification and typing of herpes simplex virus types 1 and 2 by monoclonal antibodies, sensitivity to the drug (E)-5-(2-bromovinyl)-2'-deoxyuridine, and restriction endonuclease analysis of viral DNA.通过单克隆抗体对1型和2型单纯疱疹病毒进行鉴定和分型、对药物（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的敏感性以及病毒DNA的限制性内切酶分析。
J Med Virol. 1985 Mar;15(3):215-22. doi: 10.1002/jmv.1890150302.
8
Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy.E-5-丙烯基-2'-脱氧尿苷的抗单纯疱疹病毒和抗人细胞生长活性以及抗病毒化疗中的选择性保护概念。
Antimicrob Agents Chemother. 1980 Dec;18(6):957-61. doi: 10.1128/AAC.18.6.957.
9
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.5-[(甲硫基)甲基]-2'-脱氧尿苷、相应的亚砜和砜及其5'-磷酸酯的合成：抗病毒作用及胸苷酸合成酶抑制作用
J Med Chem. 1980 Mar;23(3):252-6. doi: 10.1021/jm00177a008.
10
Serotyping of herpes simplex virus isolates: a comparison of BVDU sensitivities, indirect immunofluorescence with monoclonal antibodies, and indirect immunofluorescence with cross-adsorbed rabbit antibodies.单纯疱疹病毒分离株的血清分型：BVDU敏感性、单克隆抗体间接免疫荧光法及交叉吸附兔抗体间接免疫荧光法的比较
J Virol Methods. 1983 Oct;7(4):199-206. doi: 10.1016/0166-0934(83)90009-5.

引用本文的文献

1
Current recommendations for the treatment of genital herpes.当前生殖器疱疹的治疗建议。
Drugs. 2000 Dec;60(6):1329-52. doi: 10.2165/00003495-200060060-00007.
2
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对无毛小鼠皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1984 Aug;26(2):155-9. doi: 10.1128/AAC.26.2.155.
3
Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs.局部应用5-乙基-2'-脱氧尿苷与阿昔洛韦治疗豚鼠皮肤单纯疱疹病毒感染的比较。
Antimicrob Agents Chemother. 1985 Jul;28(1):103-6. doi: 10.1128/AAC.28.1.103.
4
The role of oral acyclovir in the management of genital herpes simplex.口服阿昔洛韦在单纯疱疹性生殖器感染治疗中的作用
CMAJ. 1987 Apr 1;136(7):701-7.
5
Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs.5-乙基-2'-脱氧尿苷在细胞培养、小鼠和豚鼠中对单纯疱疹病毒的抗病毒活性。
Antimicrob Agents Chemother. 1985 Oct;28(4):552-60. doi: 10.1128/AAC.28.4.552.

本文引用的文献

1
Therapy in genital herpes.
N Engl J Med. 1982 Jun 3;306(22):1356-7. doi: 10.1056/NEJM198206033062209.
2
Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates.临床分离株中存在对高浓度阿昔洛韦耐药的单纯疱疹病毒变种。
Antimicrob Agents Chemother. 1982 Jul;22(1):71-7. doi: 10.1128/AAC.22.1.71.
3
Spectrum of sensitivity of acyclovir of herpes simplex virus clinical isolates.单纯疱疹病毒临床分离株对阿昔洛韦的敏感性谱
Am J Med. 1982 Jul 20;73(1A):376-9. doi: 10.1016/0002-9343(82)90126-7.
4
Comparative efficacy of antiherpes drugs in different cell lines.抗疱疹药物在不同细胞系中的比较疗效。
Antimicrob Agents Chemother. 1982 Apr;21(4):661-3. doi: 10.1128/AAC.21.4.661.
5
Differentiation of herpes simplex virus types 1 and 2 by sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.通过对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的敏感性区分1型和2型单纯疱疹病毒
J Clin Microbiol. 1982 Apr;15(4):733-6. doi: 10.1128/jcm.15.4.733-736.1982.
6
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.关于（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对疱疹病毒复制的选择性抑制机制
Proc Natl Acad Sci U S A. 1981 May;78(5):2698-702. doi: 10.1073/pnas.78.5.2698.
7
Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.
J Biol Chem. 1981 Jun 25;256(12):5973-6.
8
Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.抗疱疹药物对不同株单纯疱疹病毒的比较疗效
J Infect Dis. 1980 May;141(5):563-74. doi: 10.1093/infdis/141.5.563.
9
Serological analysis of herpes simplex virus types 1 and 2 with monoclonal antibodies.用单克隆抗体对1型和2型单纯疱疹病毒进行血清学分析。
Infect Immun. 1982 Jan;35(1):363-7. doi: 10.1128/iai.35.1.363-367.1982.
10
Deoxyribopyrimidine triphosphatase activity specific for cells infected with herpes simplex virus type 1.针对单纯疱疹病毒1型感染细胞的脱氧核糖嘧啶三磷酸酶活性
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1872-6. doi: 10.1073/pnas.77.4.1872.

单纯疱疹病毒近期临床分离株对5-乙基-2'-脱氧尿苷的敏感性：对2型单纯疱疹病毒的优先抑制作用

Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.

作者信息

Teh C Z, Sacks S L

出版信息

Antimicrob Agents Chemother. 1983 May;23(5):637-40. doi: 10.1128/AAC.23.5.637.

DOI:10.1128/AAC.23.5.637
PMID:6307130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC184779/
Abstract

We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a type 2-preferential but not a type 2-specific antiviral effect. Utilizing a microtiter assay with BHK-21 cells, we found that the mean (+/- standard deviation) 50% inhibitory dose for herpes simplex virus type 1 isolates was 0.58 +/- 0.30 micrograms/ml as compared with 0.33 +/- 0.20 microgram/ml for herpes simplex virus type 2 isolates. Isolates were typed according to their susceptibilities to (E)-5-(2-bromovinyl)-2'-deoxyuridine and by an indirect fluorescent-antibody technique in which monoclonal antibody combinations were used. A cytotoxicity assay in which the incorporation of [1',2'-3H]deoxyuridine was measured revealed a 50% inhibitory dose of 37.5 micrograms/ml, suggesting a favorable therapeutic index for this compound.

摘要

我们检测了3株参考毒株和41株近期单纯疱疹病毒1型和2型临床分离株对5-乙基-2'-脱氧尿苷的体外敏感性。这种胸苷类似物具有2型偏好性但并非2型特异性的抗病毒作用。利用BHK-21细胞进行微量滴定试验，我们发现单纯疱疹病毒1型分离株的平均（±标准差）50%抑制剂量为0.58±0.30微克/毫升，而单纯疱疹病毒2型分离株为0.33±0.20微克/毫升。根据分离株对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的敏感性以及使用单克隆抗体组合的间接荧光抗体技术对分离株进行分型。通过测量[1',2'-3H]脱氧尿苷掺入量的细胞毒性试验显示50%抑制剂量为37.5微克/毫升，表明该化合物具有良好的治疗指数。