Goldobenko G V, Ivanov V K, Durenov L A, Lobanov G V, Waĭnson A A
Med Radiol (Mosk). 1990 Jan;35(1):14-7.
Radiation therapy is widely used in pediatric oncology. Its use emphasizes the problems of the protection of growing tissues and organs. The paper is concerned with the problem of effective distribution of an ionizing radiation dose delivered to a locally advanced tumor in children. Analysis of the literature and authors' data show that the growing organs of a child are 2-2.5-fold more sensitive than the same organs of an adult. Besides some organs and tissues at various ages of a child possess a various degree of maturity. Therefore it is proposed that small single doses (0.6-1 Gy) that can be delivered 2-3 times a day, should be used in pediatric oncology. A scheme of dynamic irradiation of radiosensitive and resistant tumors of children was prepared and tested under clinical conditions.
放射治疗在儿科肿瘤学中被广泛应用。其应用突出了生长中组织和器官的保护问题。本文关注的是儿童局部晚期肿瘤电离辐射剂量的有效分布问题。文献分析和作者的数据表明，儿童生长中的器官比成人相同器官的敏感性高2至2.5倍。此外，儿童不同年龄段的一些器官和组织具有不同程度的成熟度。因此，建议在儿科肿瘤学中使用可一天给予2至3次的小单次剂量（0.6至1 Gy）。制定并在临床条件下测试了儿童放射敏感和抗辐射肿瘤的动态照射方案。
