Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Clin Chim Acta. 2013 May;420:28-33. doi: 10.1016/j.cca.2012.10.025. Epub 2012 Oct 16.
Fast analysis of chemicals in samples of complex mixtures is important for many analytical applications including therapeutic drug monitoring and food safety screening.
Based on the paper spray technology developed recently, a high throughput device was developed in this work and used for evaluation of the fast quantitative analysis using paper spray mass spectrometry.
The performance of the method was characterized with bovine blood samples spiked with sunitinib and nicotine. At optimized condition, relatively fast analysis speed of 7s/sample was achieved with relatively good LOQs (1 ng/ml) and quantitation.
In an application of the method for food screening, LODs better than 1 ng/g were achieved for clenbuterol in beef.
快速分析复杂混合物样品中的化学物质对于许多分析应用非常重要，包括治疗药物监测和食品安全筛选。
基于最近开发的纸喷雾技术，本工作中开发了一种高通量装置，并用于评估使用纸喷雾质谱进行快速定量分析。
该方法的性能采用牛血样品进行了表征，样品中加入了舒尼替尼和尼古丁。在优化条件下，以相对较快的 7s/sample 的分析速度，实现了相对较好的 LOQs（1ng/ml）和定量。
在该方法应用于食品筛选的实例中，在牛肉中检测到克仑特罗的检测限优于 1ng/g。
