Dept. of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Int J Med Microbiol. 2012 Dec;302(7-8):289-92. doi: 10.1016/j.ijmm.2012.09.003. Epub 2012 Oct 22.
Meningitis in adults due to infection with Mycoplasma hominis is rarely reported. Here, we document the third case of M. hominis meningitis in an adult individual, developed upon neurosurgery following a subarachnoid haemorrhage. Our findings are noteworthy, because the presence of M. hominis in cerebrospinal fluid cannot be identified by standard culturing, Gram-staining, or matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Importantly, however, 16S rDNA sequencing did lead to an unambiguous diagnosis and guided successful antimicrobial therapy. Based on our present findings and a review of the respective literature, we conclude that M. hominis should be considered as a candidate causative agent of infections of the central nervous system following neurosurgical procedures, especially if there is no response to standard antimicrobial therapy, and routine culturing yields negative results.
由人型支原体引起的成人脑膜炎很少见报道。在此，我们报告了第三位成人感染人型支原体脑膜炎的病例，该患者在蛛网膜下腔出血后继发神经外科手术后发生。我们的发现值得注意，因为标准培养、革兰氏染色或基质辅助激光解吸电离飞行时间质谱法无法识别脑脊液中人型支原体的存在。然而，重要的是，16S rDNA 测序确实可以做出明确的诊断，并指导成功的抗菌治疗。基于我们目前的发现和对相关文献的回顾，我们得出结论，人型支原体应被视为神经外科手术后中枢神经系统感染的候选病原体，尤其是在标准抗菌治疗无反应且常规培养结果为阴性时。
