Mao Wei-Ying, Lan Jiang-Er, Gan Ming-Yu, Zhang Xun-Jie, Yu Hui, Hu Li-Yuan, Zhang Rong, Cao Yun, Xiao Mi-Li
Department of Neonatology, Children's Hospital of Fudan University/National Children's Medical Center, Shanghai 201102, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Apr 15;26(4):432-436. doi: 10.7499/j.issn.1008-8830.2312016.
The patient, a male newborn, was admitted to the hospital 2 hours after birth due to prematurity (gestational age 27 weeks) and respiratory distress occurring 2 hours postnatally. After admission, the infant developed fever and elevated C-reactive protein levels. On the fourth day after birth, metagenomic next-generation sequencing of cerebrospinal fluid indicated a positive result for (9 898 reads). On the eighth day, a retest of cerebrospinal fluid metagenomics confirmed (56 806 reads). The diagnosis of purulent meningitis caused by was established, and the antibiotic treatment was switched to moxifloxacin [5 mg/(kg·day)] administered intravenously for a total of 4 weeks. After treatment, the patient's cerebrospinal fluid tests returned to normal, and he was discharged as cured on the 76th day after birth. This article focuses on the diagnosis and treatment of neonatal purulent meningitis, introducing the multidisciplinary diagnosis and treatment of the condition in extremely preterm infants.
该患者为男性新生儿，因早产（孕龄27周）及出生后2小时出现呼吸窘迫于出生后2小时入院。入院后，婴儿出现发热且C反应蛋白水平升高。出生后第4天，脑脊液宏基因组下一代测序显示[具体病原体名称未给出，原文此处缺失]阳性结果（9898条 reads）。第8天，脑脊液宏基因组学复查确认[具体病原体名称未给出，原文此处缺失]（56806条 reads）。确诊为由[具体病原体名称未给出，原文此处缺失]引起的化脓性脑膜炎，抗生素治疗改为静脉注射莫西沙星[5毫克/（千克·天）]，共治疗4周。治疗后，患者脑脊液检查恢复正常，于出生后第76天治愈出院。本文重点关注新生儿[具体病原体名称未给出，原文此处缺失]化脓性脑膜炎的诊断与治疗，介绍极早产儿该病症的多学科诊断与治疗。
