Vivas Dan, Inga Rosío, Yarlequé Armando
Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Perú.
Rev Peru Med Exp Salud Publica. 2012 Jul-Sep;29(3):396-401. doi: 10.1590/s1726-46342012000300017.
Cancer can develop to the extent tumor cells grow, divide and grow into other body tissues. Integrins are a family of cell-surface heterodimeric receptors that play an important role in the development of tumor angiogenesis, growth and metastasis, thus being recognized as an attractive therapeutic target. Snake venom contains low-molecular weight peptides known as "disintegrins" that bind to integrins with high affinity, and prevent their action in cancer. In the next article, we go over the results of investigations, both in vitro and in vivo, which have shown promising results, thus revealing that the use of disintegrins could be a promising alternative for the treatment of different neoplasias.
癌症会发展到肿瘤细胞生长、分裂并侵入身体其他组织的程度。整合素是一类细胞表面异二聚体受体，在肿瘤血管生成、生长和转移过程中发挥重要作用，因此被视为一个有吸引力的治疗靶点。蛇毒含有低分子量肽，即所谓的“去整合素”，它们能与整合素高亲和力结合，并阻止其在癌症中的作用。在下一篇文章中，我们将探讨体外和体内研究的结果，这些结果显示出了有前景的成果，从而表明使用去整合素可能是治疗不同肿瘤的一种有前景的替代方法。
