Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.
Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Eur J Pharmacol. 2021 May 15;899:174022. doi: 10.1016/j.ejphar.2021.174022. Epub 2021 Mar 13.
Snake venoms are a potential source of various enzymatic and non-enzymatic compounds with a defensive role for the host. Various peptides with significant medicinal properties have been isolated and characterized from these venoms. Few of these are FDA approved. They inhibit tumor cells adhesion, migration, angiogenesis and metastasis by inhibiting integrins on transmembrane cellular surfaces. This plays important role in delaying tumor growth, neovascularization and development. Tumor targeting and smaller size make them ideal candidates as novel therapeutic agents for cancer treatment. This review is based on sources of these disintegrins, their targeting modality, classification and underlying anti-cancer potential.
蛇毒是具有防御作用的各种酶和非酶化合物的潜在来源。从这些毒液中分离出并表征了具有重要药用特性的各种肽。其中少数已获得 FDA 批准。它们通过抑制跨膜细胞表面上的整合素来抑制肿瘤细胞的黏附、迁移、血管生成和转移。这在延缓肿瘤生长、新血管生成和发展方面发挥着重要作用。肿瘤靶向和较小的尺寸使它们成为癌症治疗的新型治疗剂的理想候选物。本综述基于这些整合素抑制剂的来源、它们的靶向方式、分类和潜在的抗癌潜力。
