University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA.
J Biomed Opt. 2012 Sep;17(9):96008-1. doi: 10.1117/1.JBO.17.9.096008.
Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit's thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imaging is feasible using the integrated IVUS/IVPA imaging catheter. The challenges of in vivo combined IVUS/IVPA imaging are discussed, and further improvements on the design of the catheter and the clinical imaging system are proposed.
现报道体内血管内超声(IVUS)和血管内光声(IVPA)成像的初步研究结果。对一种新开发的基于单根光纤的单元件超声换能器和光传输系统的集成 IVUS/IVPA 成像导管原型进行了改进,并将其用于在存在管腔血液的情况下对兔胸主动脉中部署的冠状动脉支架进行体内成像。结果表明,使用集成的 IVUS/IVPA 成像导管进行体内 IVUS/IVPA 成像具有可行性。本文还讨论了体内联合 IVUS/IVPA 成像的挑战,并提出了对导管和临床成像系统设计的进一步改进。