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自体胃肠道重建:短肠综合征成人和儿童的最佳非移植手术选择综述。

Autologous gastrointestinal reconstruction: review of the optimal nontransplant surgical options for adults and children with short bowel syndrome.

机构信息

Duke University Medical Center, Durham, NC, USA.

出版信息

Nutr Clin Pract. 2013 Feb;28(1):65-74. doi: 10.1177/0884533612460405. Epub 2012 Oct 18.

Abstract

Short bowel syndrome (SBS) results in loss of absorptive capacity of the development of gut, leading to malabsorption due to protein, energy, fluid, and electrolyte loss and imbalance while on enteral diet alone. Various nonsurgical and surgical therapeutic options that have emerged improve the survival outcome following SBS in both children and adults. An individualized, complex multidisciplinary approach to medical and surgical intestinal rehabilitation is needed to provide an opportunity for enteral autonomy to be possible in a patient with SBS. The remnant bowel plays a very pivotal role in autologous gastrointestinal reconstruction (AGIR) surgery. Intestinal transplantation, although promising and potentially life-saving for SBS, should be reserved for patients with failed AGIR or those who have no prospect for autologous enteral autonomy. This article reviews the evolution of nontransplant surgical management of patients with SBS.

摘要

短肠综合征(SBS)导致肠道吸收能力丧失和发育不良,仅通过肠内饮食就会导致蛋白质、能量、液体和电解质丢失和失衡,从而引起吸收不良。各种非手术和手术治疗方法的出现改善了儿童和成人 SBS 后的生存结果。需要个体化、复杂的多学科方法进行医学和手术肠道康复,为 SBS 患者提供实现肠内自主的机会。残留的肠道在自体胃肠道重建(AGIR)手术中起着非常关键的作用。尽管肠移植对 SBS 有希望并可能挽救生命,但应保留给 AGIR 失败或没有自体肠内自主可能的患者。本文回顾了 SBS 患者非移植手术治疗的演变。

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