Lang R J
Br J Pharmacol. 1979 Jul;66(3):355-7. doi: 10.1111/j.1476-5381.1979.tb10836.x.
The effects of temperature on the inhibitory junctional potential (i.j.p.) and the electrotonic potential, recorded in the circular smooth muscle of the guinea-pig ileum, were studied with intracellular microelectrodes. The amplitude and time course of the i.j.p. were both dependent on the ambient temperature, the i.j.p. becoming smaller and more prolonged as the temperature was lowered. In contrast, the electrotonic potential was not much affected by temperature. The atropine-resistant 'late' depolarization was also dependent on temperature. These results are consistent with the mechanism of release, of the nonadrenergic noncholinergic inhibitory transmitter, being sensitive to temperature and with the inhibitory conductance change, underlying the i.j.p., being long compared to the membrane time constant of the circular smooth muscle.
采用细胞内微电极研究了温度对豚鼠回肠环形平滑肌中抑制性接头电位（i.j.p.）和电紧张电位的影响。i.j.p.的幅度和时程均取决于环境温度，随着温度降低，i.j.p.变小且持续时间延长。相比之下，电紧张电位受温度影响不大。对阿托品耐受的“晚期”去极化也取决于温度。这些结果与非肾上腺素能非胆碱能抑制性递质的释放机制对温度敏感以及i.j.p.背后的抑制性电导变化与环形平滑肌的膜时间常数相比持续时间较长是一致的。
