Gilliland Sarah M, Jenkins Adrian, Parker Lauren, Somdach Nongyao, Pattamadilok Sirima, Incomserb Patcha, Berry Neil, Schepelmann Silke, Minor Philip
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.
Biologicals. 2013 Mar;41(2):84-7. doi: 10.1016/j.biologicals.2012.09.007. Epub 2012 Oct 23.
An outbreak of nine cases of mumps was reported from a total of 97 vaccinated nursing students at two medical colleges in Thailand in 2010, 16-26 days after administration of MMR vaccine containing the L-Zagreb mumps strain. Symptoms ranged in severity from fever and parotid swelling to orchitis. Clinical samples were obtained from seven patients and three were suitable for further study. Sequencing confirmed that the SH gene of the mumps virus in the unpassaged clinical specimens was identical to the L-Zagreb SH gene in the vaccine. Further analysis of the viral genome identified nucleotide position 5170 as a novel mutation which corresponds to an amino acid change in the fusion protein. This study provides another virologically confirmed example of mumps resulting from the L-Zagreb vaccine strain.
2010年，泰国两所医学院的97名接种过疫苗的护理专业学生中报告了9例腮腺炎疫情，疫情发生在接种含L-萨格勒布腮腺炎毒株的MMR疫苗后的16至26天。症状严重程度不一，从发热、腮腺肿大到睾丸炎。从7名患者身上采集了临床样本，其中3份适合进一步研究。测序证实，未经传代的临床样本中腮腺炎病毒的SH基因与疫苗中的L-萨格勒布SH基因相同。对病毒基因组的进一步分析确定核苷酸位置5170为一个新突变，该突变对应于融合蛋白中的一个氨基酸变化。这项研究提供了另一个经病毒学证实的由L-萨格勒布疫苗株导致腮腺炎的例子。
