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[女性肺癌的流行病学结果]

[Results of the epidemiology of lung cancer in females].

作者信息

Jahn I, Jöckel K H, Ahrens W, Drescher K, Müller K M, Witzko K H

机构信息

Bremer Institut für Präventionsforschung und Sozialmedizin.

出版信息

Pneumologie. 1990 Jan;44(1):14-23.

PMID:2308913
Abstract

In the context with an extensive pilot study investigating risk factors for lung cancer, aetiological and clinical questions were analysed for lung cancer mortality in women. In a first step all available data sources about the prevalence of smoking in the FRG were used to determine the correlation between the prevalence of smoking and lung cancer mortality. 88% of the variance (R2) of lung cancer mortality for women could be explained by smoking. In a second step medical records of 133 female lung cancer patients from three hospitals were analysed with regard to the histological types of lung cancer and smoking. Small cell lung cancers were more frequent among female smokers while adenocarcinoma was more prevalent among non-smokers. Survival analysis for 421 men and 97 women showed a significantly longer survival time for women as compared to men, taking into account other relevant prognostic factors. The association between smoking and lung cancer is discussed and analysed in greater detail.

摘要

在一项广泛的肺癌危险因素初步研究中,分析了女性肺癌死亡的病因学和临床问题。第一步,利用联邦德国所有关于吸烟流行率的可用数据源,确定吸烟流行率与肺癌死亡率之间的相关性。女性肺癌死亡率88%的方差(R2)可由吸烟来解释。第二步,分析了来自三家医院的133名女性肺癌患者的病历,涉及肺癌的组织学类型和吸烟情况。女性吸烟者中小细胞肺癌更为常见,而非吸烟者中腺癌更为普遍。对421名男性和97名女性进行的生存分析表明,考虑到其他相关预后因素,女性的生存时间明显长于男性。文中对吸烟与肺癌之间的关联进行了更详细的讨论和分析。

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