Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
Adv Chronic Kidney Dis. 2012 Nov;19(6):372-6. doi: 10.1053/j.ackd.2012.07.010.
A cross-sectional study was performed evaluating serum urate levels and fractional excretion of urate in a group of patients referred for screening for inherited metabolic disorders. From 2003 through 2010, serum urate, serum creatinine, urinary urate, and urinary creatinine levels were obtained as part of a research protocol to identify individuals with inherited metabolic disorders. These values were compared with individuals with uromodulin-associated kidney disease (UAKD). Laboratory studies were evaluated on 1274 individuals. The fractional excretion of urate was very high in infancy (27 ± 21% in males and 29 ± 25% in females). The high fractional excretion declined rapidly over the first several months of life, together with a decline in serum urate levels. The mean fractional excretion was approximately 8% during childhood. It then remained stable in females but decreased in males to 5.9 ± 5.6% in adolescence and 5.3 ± 3.8% in adulthood. Serum urate levels in childhood were influenced by age and kidney function but not gender. In adulthood, serum urate was influenced by age, gender, and estimated glomerular filtration rate. Although patients with UAKD had lower fractional excretions of urate than individuals with normal kidney function, there was considerable overlap.
一项横断面研究评估了一组遗传性代谢紊乱患者的血尿酸水平和尿酸分数排泄率。2003 年至 2010 年，作为识别遗传性代谢紊乱个体的研究方案的一部分，获得了血清尿酸、血清肌酐、尿尿酸和尿肌酐水平。将这些值与尿调素相关肾病（UAKD）患者进行了比较。对 1274 名个体进行了实验室研究。尿酸分数排泄率在婴儿期非常高（男性为 27 ± 21%，女性为 29 ± 25%）。高分数排泄率在生命的头几个月迅速下降，同时血清尿酸水平下降。儿童时期的平均分数排泄率约为 8%。然后在女性中保持稳定，但在男性中下降至青春期的 5.9 ± 5.6%和成年期的 5.3 ± 3.8%。儿童时期的血清尿酸水平受年龄和肾功能影响，但不受性别影响。在成年期，血清尿酸受年龄、性别和估计肾小球滤过率的影响。尽管 UAKD 患者的尿酸分数排泄率低于肾功能正常的个体，但存在相当大的重叠。
