Berlyne G M, Sutton J, Brown C, Caruso C, Friedman E A
Miner Electrolyte Metab. 1984;10(4):259-62.
Renal handling of urate was examined in 11 patients with nephrotic syndrome before, during, and after 4 h of water immersion up to the neck. Urinary urate excretion, urate clearance, and fractional excretion of urate all increased significantly during water immersion, and decreased in the hour following water immersion. During water immersion fractional excretion of urate rose to a maximum of 16 ml/ml of glomerular filtrate, and fell towards control levels on removal from the bath. It is concluded that either there is a decrease in proximal tubular urate reabsorption or secretion caused by water immersion. In contrast, diurnal control studies showed no significant change in fractional excretion of urate during the same period of the day. It is postulated that the increased fractional excretion of urate on water immersion is due to hypervolemia induced by the hydrostatic pressure of the water on the lower limbs and abdomen.
对11例肾病综合征患者在颈部以下浸入水中4小时之前、期间及之后的尿酸肾处理情况进行了研究。在水浸期间，尿尿酸排泄、尿酸清除率及尿酸分数排泄均显著增加，并在水浸后的一小时内降低。在水浸期间，尿酸分数排泄上升至最高16ml/每毫升肾小球滤过液，并在离开浴盆后降至对照水平。得出的结论是，水浸导致近端肾小管尿酸重吸收或分泌减少。相比之下，日间对照研究显示，在一天中的同一时段，尿酸分数排泄无显著变化。据推测，水浸时尿酸分数排泄增加是由于水对下肢和腹部的静水压力引起的血容量过多所致。
