Molecular Imaging Program, Stanford University, Stanford, 94305, USA.
Chem Commun (Camb). 2012 Dec 7;48(94):11555-7. doi: 10.1039/c2cc36264c.
Despite differences in the crystal structures of ice and nucleosides, antifreeze polypeptides (AFPs) have been demonstrated to inhibit nucleation of 5-methyluridine, cytidine, and inosine and modify the crystal growth of the nucleosides efficiently. The molecular recognition repertoire of AFPs has been expanded to non-ice-like crystalline solids.
尽管冰和核苷的晶体结构存在差异,但已证明抗冻蛋白 (AFP) 能够抑制 5-甲基尿嘧啶、胞苷和肌苷的成核,并有效地改变核苷的晶体生长。AFP 的分子识别范围已扩展到非冰状结晶固体。