Dipartimento di Chimica and IMC-CNR Sezione Meccanismi di Reazione, Università La Sapienza, 00185 Roma, Italy.
Org Biomol Chem. 2012 Dec 7;10(45):8941-3. doi: 10.1039/c2ob26688a. Epub 2012 Oct 22.
The upper rim cone tetraguanidinocalix[4]arene 1 is a highly effective catalyst of ATP hydrolysis. The catalytically most active species is the triprotonated form of the catalyst. The three protonated guanidinium groups provide the electrostatic driving force for substrate binding and activation, while the neutral guanidine most likely acts as a nucleophilic catalyst.
上缘锥形四胍基杯[4]芳烃 1 是一种高效的 ATP 水解催化剂。最具催化活性的物种是催化剂的三质子化形式。三个质子化的胍基为底物结合和活化提供静电驱动力，而中性胍基很可能充当亲核催化剂。
