透明质酸酶/ATP 串联刺激响应超分子组装。

A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly.

机构信息

College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China.

出版信息

Chem Commun (Camb). 2019 Nov 26;55(95):14387-14390. doi: 10.1039/c9cc08199b.

DOI:10.1039/c9cc08199b

PMID:31723950

Abstract

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.

摘要

我们设计了一种基于胍基修饰杯[5]芳烃（GC5A-6C）和吖啶黄修饰透明质酸（EY-HA）的串联刺激响应组装体，该组装体在透明质酸酶的触发下发生解组装，并在 ATP 的激活下释放 EY。透明质酸酶和 ATP 均为肿瘤生物标志物，因此，该体系在肿瘤光疗方面具有精准递药的潜力。