New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII).
作者信息
Rokita Adam G, Anderson Mark E
机构信息
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
出版信息
Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
Abstract
摘要
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本文引用的文献
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Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.钙/钙调蛋白依赖性蛋白激酶 II（CaMKII）通过多个磷酸化位点调节心脏钠离子通道 NaV1.5 的门控。
J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18.
2
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.在慢性心房颤动患者中，增强的肌浆网 Ca2+ 泄漏和增加的 Na+-Ca2+ 交换器功能是延迟后除极的基础。
Circulation. 2012 May 1;125(17):2059-70. doi: 10.1161/CIRCULATIONAHA.111.067306. Epub 2012 Mar 28.
3
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.MyD88 介导的炎症信号导致心肌梗死后的 CaMKII 氧化、心脏肥大和死亡。
J Mol Cell Cardiol. 2012 May;52(5):1135-44. doi: 10.1016/j.yjmcc.2012.01.021. Epub 2012 Feb 3.
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Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.短缩的 Ca2+ 信号不应期是心肌梗死后心源性猝死模型中细胞心律失常发生的基础。
Circ Res. 2012 Feb 17;110(4):569-77. doi: 10.1161/CIRCRESAHA.111.260455. Epub 2012 Jan 5.
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Nat Med. 2011 Nov 13;17(12):1610-8. doi: 10.1038/nm.2506.
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Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes.位置很重要：澄清核和胞质 CaMKII 亚型的概念。
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A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.一种人类 Ca2+/钙调蛋白依赖性激酶 II 全酶结构中可调自抑制的机制。
Cell. 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038.
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Oxidized CaMKII causes cardiac sinus node dysfunction in mice.氧化型 CaMKII 导致小鼠心脏窦房结功能障碍。
J Clin Invest. 2011 Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25.
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CaMKII in the cardiovascular system: sensing redox states.钙调蛋白依赖性蛋白激酶 II 在心血管系统中的作用：感知氧化还原状态。
Physiol Rev. 2011 Jul;91(3):889-915. doi: 10.1152/physrev.00018.2010.
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Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.Nav1.5 依赖性持续钠离子内流激活大鼠心室肌细胞和 N1325S 小鼠中的 CaMKII。
Am J Physiol Cell Physiol. 2011 Sep;301(3):C577-86. doi: 10.1152/ajpcell.00125.2011. Epub 2011 Jun 15.
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