Asero R
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, MI, Italy.
Eur Ann Allergy Clin Immunol. 2012 Aug;44(4):157-9.
Previous surveys performed in this area showed that the age at onset of ragweed allergy in monosensitized subjects is about 35.
To detect whether a reduction in the mean age of ragweed sensitization in the area of Milan has taken place after the last survey.
All patients developing clinical ragweed pollen allergy in the years 2007-2010 and monosensitized to this allergen seen were included. 30 randomly selected subjects already sensitized to at least one other allergen source among grass, pellitory, or mite who developed ragweed allergy during the same period served as controls.
The 137 patients showed a median age at onset of ragweed allergy of 36-40 years in the years 2007-2010 with no tendency to reduction. About 10% of patients were < 20 years old in 3 of the 4 study years. 15% of patients were > 50 years old at onset, and 3 of them were > 70. In the control group the mean age at onset of ragweed allergy was 31,6 years (median 32,5 years; range 10-60; p < 0.001 vs patients).
In this area monosensitization to ragweed occurs steadily at an adult age. In already allergic subjects it occurs at a younger age. The age at onset of allergy to one specific airborne allergen source seems to depend on several variables, including exposure duration, atopic status, and specific features of the allergen.
此前在该地区进行的调查显示，单一致敏患者中豚草过敏的发病年龄约为35岁。
检测在米兰地区上次调查之后，豚草致敏的平均年龄是否有所降低。
纳入了2007年至2010年间出现临床豚草花粉过敏且对该过敏原单一致敏的所有患者。随机选择30名在同一时期对草、墙草或螨等至少一种其他过敏原致敏且出现豚草过敏的受试者作为对照。
137例患者在2007年至2010年间豚草过敏的发病年龄中位数为36至40岁，没有降低的趋势。在4个研究年份中的3年里，约10%的患者年龄小于20岁。15%的患者发病时年龄大于50岁，其中3人年龄大于70岁。在对照组中，豚草过敏的平均发病年龄为31.6岁（中位数32.5岁；范围10至60岁；与患者相比p<0.001）。
在该地区，对豚草的单一致敏在成年期稳定发生。在已经过敏的受试者中，发病年龄较小。对一种特定空气传播过敏原的过敏发病年龄似乎取决于几个变量，包括接触持续时间、特应性状态和过敏原的特定特征。
